Comparison of in-vitro and in-vivo response to fetal hemoglobin production and γ-mRNA expression by hydroxyurea in Hemoglobinopathies

BACKGROUND: Hydroxyurea, which induces Fetal hemoglobin (HbF) synthesis, is the only drug widely used in different hemoglobinopathies; however, the response is very variable. We compared the efficacy of hydroxyurea in-vitro in erythroid cultures and in-vivo in the same patients with different hemogl...

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Detalles Bibliográficos
Autores principales: Italia, Khushnooma, Jijina, Farah, Merchant, Rashid, Swaminathan, Suchitra, Nadkarni, Anita, Gupta, Maya, Ghosh, Kanjaksha, Colah, Roshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758735/
https://www.ncbi.nlm.nih.gov/pubmed/24019630

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