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Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study

BACKGROUND: The relationship between surgical margin and local recurrence (LR) in osteosarcoma patients with poor responses to chemotherapy is unclear. Moreover, the incidences of LR according to three different resection planes (bone, soft tissue, and perineurovascular) are not commonly known. METH...

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Autores principales: Jeon, Dae-Geun, Song, Won Seok, Kong, Chang-Bae, Cho, Wan Hyeong, Cho, Sang Hyun, Lee, Jeong Dong, Lee, Soo-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Orthopaedic Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758992/
https://www.ncbi.nlm.nih.gov/pubmed/24009908
http://dx.doi.org/10.4055/cios.2013.5.3.216
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author Jeon, Dae-Geun
Song, Won Seok
Kong, Chang-Bae
Cho, Wan Hyeong
Cho, Sang Hyun
Lee, Jeong Dong
Lee, Soo-Yong
author_facet Jeon, Dae-Geun
Song, Won Seok
Kong, Chang-Bae
Cho, Wan Hyeong
Cho, Sang Hyun
Lee, Jeong Dong
Lee, Soo-Yong
author_sort Jeon, Dae-Geun
collection PubMed
description BACKGROUND: The relationship between surgical margin and local recurrence (LR) in osteosarcoma patients with poor responses to chemotherapy is unclear. Moreover, the incidences of LR according to three different resection planes (bone, soft tissue, and perineurovascular) are not commonly known. METHODS: We evaluated the incidence of LR in three areas. To assess whether there is a role of surgical margin on LR in patients resistant to preoperative chemotherapy, we designed a case (35 patients with LR) and control (70 patients without LR) study. Controls were matched for age, location, initial tumor volume, and tumor volume change during preoperative chemotherapy. RESULTS: LR occurred at the soft tissues in 18 cases (51.4%), at the perineurovascular tissues in 11 cases (31.4%), and at the bones in six cases (17.2%). The proportion of inadequate perineurovascular margin was higher in the case group than in the control group (p = 0.01). Within case-control group (105 patients), a correlation between each margin status and LR at corresponding area was found in the bone (p < 0.001) and perineurovascular area (p = 0.001). CONCLUSIONS: LR is most common in soft tissues. In patients showing similar unfavorable responses to chemotherapy, the losses of perineurovascular fat plane on preoperative magnetic resonance imaging may be a valuable finding in predicting LR.
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spelling pubmed-37589922013-09-04 Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study Jeon, Dae-Geun Song, Won Seok Kong, Chang-Bae Cho, Wan Hyeong Cho, Sang Hyun Lee, Jeong Dong Lee, Soo-Yong Clin Orthop Surg Original Article BACKGROUND: The relationship between surgical margin and local recurrence (LR) in osteosarcoma patients with poor responses to chemotherapy is unclear. Moreover, the incidences of LR according to three different resection planes (bone, soft tissue, and perineurovascular) are not commonly known. METHODS: We evaluated the incidence of LR in three areas. To assess whether there is a role of surgical margin on LR in patients resistant to preoperative chemotherapy, we designed a case (35 patients with LR) and control (70 patients without LR) study. Controls were matched for age, location, initial tumor volume, and tumor volume change during preoperative chemotherapy. RESULTS: LR occurred at the soft tissues in 18 cases (51.4%), at the perineurovascular tissues in 11 cases (31.4%), and at the bones in six cases (17.2%). The proportion of inadequate perineurovascular margin was higher in the case group than in the control group (p = 0.01). Within case-control group (105 patients), a correlation between each margin status and LR at corresponding area was found in the bone (p < 0.001) and perineurovascular area (p = 0.001). CONCLUSIONS: LR is most common in soft tissues. In patients showing similar unfavorable responses to chemotherapy, the losses of perineurovascular fat plane on preoperative magnetic resonance imaging may be a valuable finding in predicting LR. The Korean Orthopaedic Association 2013-09 2013-08-20 /pmc/articles/PMC3758992/ /pubmed/24009908 http://dx.doi.org/10.4055/cios.2013.5.3.216 Text en Copyright © 2013 by The Korean Orthopaedic Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jeon, Dae-Geun
Song, Won Seok
Kong, Chang-Bae
Cho, Wan Hyeong
Cho, Sang Hyun
Lee, Jeong Dong
Lee, Soo-Yong
Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study
title Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study
title_full Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study
title_fullStr Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study
title_full_unstemmed Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study
title_short Role of Surgical Margin on Local Recurrence in High Risk Extremity Osteosarcoma: A Case-Controlled Study
title_sort role of surgical margin on local recurrence in high risk extremity osteosarcoma: a case-controlled study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758992/
https://www.ncbi.nlm.nih.gov/pubmed/24009908
http://dx.doi.org/10.4055/cios.2013.5.3.216
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