Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl. Mutations in the RDU resulted in accumulation of polyubiquitinated forms of Dvl, which we...

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Detalles Bibliográficos
Autores principales: Jung, H, Kim, B-G, Han, W H, Lee, J H, Cho, J-Y, Park, W S, Maurice, M M, Han, J-K, Lee, M J, Finley, D, Jho, E-h
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759127/
https://www.ncbi.nlm.nih.gov/pubmed/23958854
http://dx.doi.org/10.1038/oncsis.2013.28

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