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Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic?

Cancers of the colon and rectum, which rank among the most frequent human tumors, are currently treated by surgical resection in locally restricted tumor stages. However, disease recurrence and formation of local and distant metastasis frequently occur even in cases with successful curative resectio...

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Detalles Bibliográficos
Autores principales: Shibayama, Masaki, Maak, Matthias, Nitsche, Ulrich, Gotoh, Kengo, Rosenberg, Robert, Janssen, Klaus-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759175/
https://www.ncbi.nlm.nih.gov/pubmed/24212936
http://dx.doi.org/10.3390/cancers3032858
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author Shibayama, Masaki
Maak, Matthias
Nitsche, Ulrich
Gotoh, Kengo
Rosenberg, Robert
Janssen, Klaus-Peter
author_facet Shibayama, Masaki
Maak, Matthias
Nitsche, Ulrich
Gotoh, Kengo
Rosenberg, Robert
Janssen, Klaus-Peter
author_sort Shibayama, Masaki
collection PubMed
description Cancers of the colon and rectum, which rank among the most frequent human tumors, are currently treated by surgical resection in locally restricted tumor stages. However, disease recurrence and formation of local and distant metastasis frequently occur even in cases with successful curative resection of the primary tumor (R0). Recent technological advances in molecular diagnostic analysis have led to a wealth of knowledge about the changes in gene transcription in all stages of colorectal tumors. Differential gene expression, or transcriptome analysis, has been proposed by many groups to predict disease recurrence, clinical outcome, and also response to therapy, in addition to the well-established clinico-pathological factors. However, the clinical usability of gene expression profiling as a reliable and robust prognostic tool that allows evidence-based clinical decisions is currently under debate. In this review, we will discuss the most recent data on the prognostic significance and potential clinical application of genome wide expression analysis in colorectal cancer.
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spelling pubmed-37591752013-09-04 Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic? Shibayama, Masaki Maak, Matthias Nitsche, Ulrich Gotoh, Kengo Rosenberg, Robert Janssen, Klaus-Peter Cancers (Basel) Review Cancers of the colon and rectum, which rank among the most frequent human tumors, are currently treated by surgical resection in locally restricted tumor stages. However, disease recurrence and formation of local and distant metastasis frequently occur even in cases with successful curative resection of the primary tumor (R0). Recent technological advances in molecular diagnostic analysis have led to a wealth of knowledge about the changes in gene transcription in all stages of colorectal tumors. Differential gene expression, or transcriptome analysis, has been proposed by many groups to predict disease recurrence, clinical outcome, and also response to therapy, in addition to the well-established clinico-pathological factors. However, the clinical usability of gene expression profiling as a reliable and robust prognostic tool that allows evidence-based clinical decisions is currently under debate. In this review, we will discuss the most recent data on the prognostic significance and potential clinical application of genome wide expression analysis in colorectal cancer. Molecular Diversity Preservation International (MDPI) 2011-07-07 /pmc/articles/PMC3759175/ /pubmed/24212936 http://dx.doi.org/10.3390/cancers3032858 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Shibayama, Masaki
Maak, Matthias
Nitsche, Ulrich
Gotoh, Kengo
Rosenberg, Robert
Janssen, Klaus-Peter
Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic?
title Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic?
title_full Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic?
title_fullStr Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic?
title_full_unstemmed Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic?
title_short Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic?
title_sort prediction of metastasis and recurrence in colorectal cancer based on gene expression analysis: ready for the clinic?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759175/
https://www.ncbi.nlm.nih.gov/pubmed/24212936
http://dx.doi.org/10.3390/cancers3032858
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