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Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy
Fibromatosis, or extra-abdominal desmoid tumor, is a benign disease which often has an aggressive clinical course that can be difficult to treat. We performed a retrospective review of 16 patients (12 females and four males) with a mean age of 34.2 years treated with methotrexate and vinblastine for...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759201/ https://www.ncbi.nlm.nih.gov/pubmed/24212959 http://dx.doi.org/10.3390/cancers3033394 |
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author | Montgomery, Corey Emory, Cynthia Adams, Sheila Cohen, Jonathan Pitcher, John David Potter, Benjamin Kyle Temple, H. Thomas |
author_facet | Montgomery, Corey Emory, Cynthia Adams, Sheila Cohen, Jonathan Pitcher, John David Potter, Benjamin Kyle Temple, H. Thomas |
author_sort | Montgomery, Corey |
collection | PubMed |
description | Fibromatosis, or extra-abdominal desmoid tumor, is a benign disease which often has an aggressive clinical course that can be difficult to treat. We performed a retrospective review of 16 patients (12 females and four males) with a mean age of 34.2 years treated with methotrexate and vinblastine for newly diagnosed or recurrent extra-abdominal desmoid tumor. The mean age of our patient cohort was 34.2 years (range 11–70), and the mean tumor size was 11.5 cm (range 2.5–21.2 cm). The mean duration of therapy was 12 months with an average follow-up of 43 months (range 1–149 months). Fourteen of 16 patients demonstrated a clinical response to treatment. Eight of 14 patients demonstrated a radiologic decrease in tumor size. Only one patient progressed on therapy. Six patients developed recurrent symptoms after discontinuation of treatment. Chemotherapy-related symptoms including neutropenia, nausea, and vomiting were common and observed in most patients, however these side effects were mild and transient. Five patients developed peripheral neuropathy that prompted a change from vinblastine to vinorelbine during treatment. One potentially life-threatening complication (pneumocystis pneumonia) occurred which was diagnosed early and successfully treated. The use of methotrexate and vinblastine/vinorelbine in the management of fibromatosis appears to be an effective treatment with minimal treatment-related side effects. |
format | Online Article Text |
id | pubmed-3759201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37592012013-09-04 Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy Montgomery, Corey Emory, Cynthia Adams, Sheila Cohen, Jonathan Pitcher, John David Potter, Benjamin Kyle Temple, H. Thomas Cancers (Basel) Article Fibromatosis, or extra-abdominal desmoid tumor, is a benign disease which often has an aggressive clinical course that can be difficult to treat. We performed a retrospective review of 16 patients (12 females and four males) with a mean age of 34.2 years treated with methotrexate and vinblastine for newly diagnosed or recurrent extra-abdominal desmoid tumor. The mean age of our patient cohort was 34.2 years (range 11–70), and the mean tumor size was 11.5 cm (range 2.5–21.2 cm). The mean duration of therapy was 12 months with an average follow-up of 43 months (range 1–149 months). Fourteen of 16 patients demonstrated a clinical response to treatment. Eight of 14 patients demonstrated a radiologic decrease in tumor size. Only one patient progressed on therapy. Six patients developed recurrent symptoms after discontinuation of treatment. Chemotherapy-related symptoms including neutropenia, nausea, and vomiting were common and observed in most patients, however these side effects were mild and transient. Five patients developed peripheral neuropathy that prompted a change from vinblastine to vinorelbine during treatment. One potentially life-threatening complication (pneumocystis pneumonia) occurred which was diagnosed early and successfully treated. The use of methotrexate and vinblastine/vinorelbine in the management of fibromatosis appears to be an effective treatment with minimal treatment-related side effects. Molecular Diversity Preservation International (MDPI) 2011-08-25 /pmc/articles/PMC3759201/ /pubmed/24212959 http://dx.doi.org/10.3390/cancers3033394 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Montgomery, Corey Emory, Cynthia Adams, Sheila Cohen, Jonathan Pitcher, John David Potter, Benjamin Kyle Temple, H. Thomas Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy |
title | Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy |
title_full | Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy |
title_fullStr | Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy |
title_full_unstemmed | Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy |
title_short | Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy |
title_sort | treatment of extra — abdominal desmoid tumors with chemotherapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759201/ https://www.ncbi.nlm.nih.gov/pubmed/24212959 http://dx.doi.org/10.3390/cancers3033394 |
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