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IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

BACKGROUND: The non-canonical NF-κB activating kinase IKKα, encoded by CHUK (conserved-helix-loop-helix-ubiquitous-kinase), has been reported to modulate pro- or anti- inflammatory responses, cellular survival and cellular differentiation. Here, we have investigated the mechanism of action of IKKα a...

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Detalles Bibliográficos
Autores principales:	Olivotto, Eleonora, Otero, Miguel, Astolfi, Annalisa, Platano, Daniela, Facchini, Annalisa, Pagani, Stefania, Flamigni, Flavio, Facchini, Andrea, Goldring, Mary B., Borzì, Rosa Maria, Marcu, Kenneth B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759388/ https://www.ncbi.nlm.nih.gov/pubmed/24023802 http://dx.doi.org/10.1371/journal.pone.0073024

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