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Blocking Plasmodium falciparum Development via Dual Inhibition of Hemoglobin Degradation and the Ubiquitin Proteasome System by MG132

Among key potential drug target proteolytic systems in the malaria parasite Plasmodium falciparum are falcipains, a family of hemoglobin-degrading cysteine proteases, and the ubiquitin proteasomal system (UPS), which has fundamental importance in cellular protein turnover. Inhibition of falcipains b...

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Detalles Bibliográficos
Autores principales:	Prasad, Rajesh, Atul, Kolla, Venkata Karunakar, Legac, Jennifer, Singhal, Neha, Navale, Rahul, Rosenthal, Philip J., Sijwali, Puran Singh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759421/ https://www.ncbi.nlm.nih.gov/pubmed/24023882 http://dx.doi.org/10.1371/journal.pone.0073530

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