Cargando…

Gene Network Analysis in a Pediatric Cohort Identifies Novel Lung Function Genes

Lung function is a heritable trait and serves as an important clinical predictor of morbidity and mortality for pulmonary conditions in adults, however, despite its importance, no studies have focused on uncovering pediatric-specific loci influencing lung function. To identify novel genetic determin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ong, Bruce A., Li, Jin, McDonough, Joseph M., Wei, Zhi, Kim, Cecilia, Chiavacci, Rosetta, Mentch, Frank, Caboot, Jason B., Spergel, Jonathan, Allen, Julian L., Sleiman, Patrick M. A., Hakonarson, Hakon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759429/ https://www.ncbi.nlm.nih.gov/pubmed/24023788 http://dx.doi.org/10.1371/journal.pone.0072899

Ejemplares similares

Systematic data-querying of large pediatric biorepository identifies novel Ehlers-Danlos Syndrome variant
por: Desai, Akshatha, et al.
Publicado: (2016)

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature
por: Zhao, Jianhua, et al.
Publicado: (2010)

COVID-19 in pediatrics: Genetic susceptibility
por: Glessner, Joseph T., et al.
Publicado: (2022)

An electronic health record (EHR) phenotype algorithm to identify patients with attention deficit hyperactivity disorders (ADHD) and psychiatric comorbidities
por: Slaby, Isabella, et al.
Publicado: (2022)

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci
por: Bradfield, Jonathan P., et al.
Publicado: (2011)

A novel heterotaxy gene: Expansion of the phenotype of TTC21B‐spectrum disease
por: Strong, Alanna, et al.
Publicado: (2021)

Metabolomic profiling for dyslipidemia in pediatric patients with sickle cell disease, on behalf of the IHCC consortium
por: Qu, Hui-Qi, et al.
Publicado: (2022)

Genetic Variation in Genes Encoding Airway Epithelial Potassium Channels Is Associated with Chronic Rhinosinusitis in a Pediatric Population
por: Purkey, Michael T., et al.
Publicado: (2014)

Assessing the functional consequence of loss of function variants using electronic medical record and large-scale genomics consortium efforts
por: Sleiman, Patrick, et al.
Publicado: (2014)

The missense variation landscape of FTO, MC4R and TMEM18 in obese children of African ancestry
por: Deliard, Sandra, et al.
Publicado: (2013)

Molecular diagnosis and novel genes and phenotypes in a pediatric thoracic insufficiency cohort
por: Strong, Alanna, et al.
Publicado: (2023)

HIF-1α Pulmonary Phenotype Wide Association Study Unveils a Link to Inflammatory Airway Conditions
por: Kelchtermans, Jelte, et al.
Publicado: (2021)

Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans
por: Qu, Hui-Qi, et al.
Publicado: (2022)

GWAS identifies four novel eosinophilic esophagitis loci
por: Sleiman, Patrick MA, et al.
Publicado: (2014)

Examination of Type 2 Diabetes Loci Implicates CDKAL1 as a Birth Weight Gene
por: Zhao, Jianhua, et al.
Publicado: (2009)

Association of a rare NOTCH4 coding variant with systemic sclerosis: a family-based whole exome sequencing study
por: Cardinale, Christopher J., et al.
Publicado: (2016)

Mitochondrial DNA haplogroups and risk of attention deficit and hyperactivity disorder in European Americans
por: Chang, Xiao, et al.
Publicado: (2020)

Genome-Wide Association Study of Serum Minerals Levels in Children of Different Ethnic Background
por: Chang, Xiao, et al.
Publicado: (2015)

Early Infantile Epileptic Encephalopathy in an STXBP1 Patient with Lactic Acidemia and Normal Mitochondrial Respiratory Chain Function
por: Li, Dong, et al.
Publicado: (2016)

Machine Learning Reduced Gene/Non-Coding RNA Features That Classify Schizophrenia Patients Accurately and Highlight Insightful Gene Clusters
por: Liu, Yichuan, et al.
Publicado: (2021)

Target Genes of Autism Risk Loci in Brain Frontal Cortex
por: Sun, Yan, et al.
Publicado: (2019)

A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling
por: Li, Dong, et al.
Publicado: (2017)

Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling
por: Li, Dong, et al.
Publicado: (2017)

Rare recurrent copy number variations in metabotropic glutamate receptor interacting genes in children with neurodevelopmental disorders
por: Glessner, Joseph T., et al.
Publicado: (2023)

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP
por: Grant, Struan F. A., et al.
Publicado: (2008)

Burden of rare coding variants reveals genetic heterogeneity between obese and non-obese asthma patients in the African American population
por: Liu, Yichuan, et al.
Publicado: (2022)

Application of deep learning algorithm on whole genome sequencing data uncovers structural variants associated with multiple mental disorders in African American patients
por: Liu, Yichuan, et al.
Publicado: (2022)

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism
por: Hadley, Dexter, et al.
Publicado: (2014)

From Disease Association to Risk Assessment: An Optimistic View from Genome-Wide Association Studies on Type 1 Diabetes
por: Wei, Zhi, et al.
Publicado: (2009)

Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI
por: Zhao, Jianhua, et al.
Publicado: (2010)

Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene
por: van Ingen, Gijs, et al.
Publicado: (2016)

Genome-wide association study reveals two loci for serum magnesium concentrations in European-American children
por: Chang, Xiao, et al.
Publicado: (2015)

Expansion of Schizophrenia Gene Network Knowledge Using Machine Learning Selected Signals From Dorsolateral Prefrontal Cortex and Amygdala RNA-seq Data
por: Liu, Yichuan, et al.
Publicado: (2022)

Genetic polymorphisms and associated susceptibility to asthma
por: March, Michael E, et al.
Publicado: (2013)

Gene correlation network analysis to identify regulatory factors in idiopathic pulmonary fibrosis
por: McDonough, John E, et al.
Publicado: (2019)

Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits
por: Li, Jin, et al.
Publicado: (2019)

1151. Candida Colonization Alters Pathogenic Pulmonary Infection in Pediatric Patients with Cystic Fibrosis
por: Parsons, Emily, et al.
Publicado: (2020)

The role of gene–ambient air pollution interactions in paediatric asthma
por: Kelchtermans, Jelte, et al.
Publicado: (2022)

Non-coding structural variation differentially impacts attention-deficit hyperactivity disorder (ADHD) gene networks in African American vs Caucasian children
por: Liu, Yichuan, et al.
Publicado: (2020)

GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
por: Sleiman, Patrick, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_sn3tek31vqepeakddgfksifml6