Selected HIV-1 Env Trimeric Formulations Act as Potent Immunogens in a Rabbit Vaccination Model

BACKGROUND: Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when formulated as a trimeric protein and in the presence...

Descripción completa

Detalles Bibliográficos
Autores principales: Heyndrickx, Leo, Stewart-Jones, Guillaume, Jansson, Marianne, Schuitemaker, Hanneke, Bowles, Emma, Buonaguro, Luigi, Grevstad, Berit, Vinner, Lasse, Vereecken, Katleen, Parker, Joe, Ramaswamy, Meghna, Biswas, Priscilla, Vanham, Guido, Scarlatti, Gabriella, Fomsgaard, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759472/
https://www.ncbi.nlm.nih.gov/pubmed/24023951
http://dx.doi.org/10.1371/journal.pone.0074552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759472/
https://www.ncbi.nlm.nih.gov/pubmed/24023951
http://dx.doi.org/10.1371/journal.pone.0074552

Ejemplares similares