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Rhabdoid Colorectal Carcinomas: Reports of Two Cases

Rhabdoid colorectal carcinomas are very rare and only 10 cases have been previously reported. We report two cases of rhabdoid colorectal carcinoma, one arising in the sigmoid colon of a 62-year-old man and another in the rectum of an 83-year-old woman. In both cases, the patients had advanced tumors...

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Autores principales: Lee, Sang Hwa, Seol, Hyesil, Kim, Wook Youn, Lim, So Dug, Kim, Wan Seop, Hwang, Tae Sook, Han, Hye Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and The Korean Society for Cytopathology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759637/
https://www.ncbi.nlm.nih.gov/pubmed/24009633
http://dx.doi.org/10.4132/KoreanJPathol.2013.47.4.372
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author Lee, Sang Hwa
Seol, Hyesil
Kim, Wook Youn
Lim, So Dug
Kim, Wan Seop
Hwang, Tae Sook
Han, Hye Seung
author_facet Lee, Sang Hwa
Seol, Hyesil
Kim, Wook Youn
Lim, So Dug
Kim, Wan Seop
Hwang, Tae Sook
Han, Hye Seung
author_sort Lee, Sang Hwa
collection PubMed
description Rhabdoid colorectal carcinomas are very rare and only 10 cases have been previously reported. We report two cases of rhabdoid colorectal carcinoma, one arising in the sigmoid colon of a 62-year-old man and another in the rectum of an 83-year-old woman. In both cases, the patients had advanced tumors with lymph node metastases. The tumors mostly showed a diffuse arrangement with rhabdoid features and small glandular regions were combined. Transitional areas from the adenocarcinomas to the rhabdoid tumors were also noted. Adenocarcinoma cells were positive for mixed cytokeratin (CK), CK20 and epithelial membranous antigen (EMA), but focal positive for vimentin. The rhabdoid tumor cells were positive for mixed CK, but focal positive or negative for CK20 and EMA. In addition, they were diffusely positive for vimentin, but negative for desmin. The histological and immunohistologial findings of these two cases suggest that the rhabodid tumor cells originated from dedifferentiated adenocarcinomas.
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spelling pubmed-37596372013-09-04 Rhabdoid Colorectal Carcinomas: Reports of Two Cases Lee, Sang Hwa Seol, Hyesil Kim, Wook Youn Lim, So Dug Kim, Wan Seop Hwang, Tae Sook Han, Hye Seung Korean J Pathol Case Study Rhabdoid colorectal carcinomas are very rare and only 10 cases have been previously reported. We report two cases of rhabdoid colorectal carcinoma, one arising in the sigmoid colon of a 62-year-old man and another in the rectum of an 83-year-old woman. In both cases, the patients had advanced tumors with lymph node metastases. The tumors mostly showed a diffuse arrangement with rhabdoid features and small glandular regions were combined. Transitional areas from the adenocarcinomas to the rhabdoid tumors were also noted. Adenocarcinoma cells were positive for mixed cytokeratin (CK), CK20 and epithelial membranous antigen (EMA), but focal positive for vimentin. The rhabdoid tumor cells were positive for mixed CK, but focal positive or negative for CK20 and EMA. In addition, they were diffusely positive for vimentin, but negative for desmin. The histological and immunohistologial findings of these two cases suggest that the rhabodid tumor cells originated from dedifferentiated adenocarcinomas. The Korean Society of Pathologists and The Korean Society for Cytopathology 2013-08 2013-08-26 /pmc/articles/PMC3759637/ /pubmed/24009633 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.4.372 Text en © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Lee, Sang Hwa
Seol, Hyesil
Kim, Wook Youn
Lim, So Dug
Kim, Wan Seop
Hwang, Tae Sook
Han, Hye Seung
Rhabdoid Colorectal Carcinomas: Reports of Two Cases
title Rhabdoid Colorectal Carcinomas: Reports of Two Cases
title_full Rhabdoid Colorectal Carcinomas: Reports of Two Cases
title_fullStr Rhabdoid Colorectal Carcinomas: Reports of Two Cases
title_full_unstemmed Rhabdoid Colorectal Carcinomas: Reports of Two Cases
title_short Rhabdoid Colorectal Carcinomas: Reports of Two Cases
title_sort rhabdoid colorectal carcinomas: reports of two cases
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759637/
https://www.ncbi.nlm.nih.gov/pubmed/24009633
http://dx.doi.org/10.4132/KoreanJPathol.2013.47.4.372
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