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Analysis of Cariogenic Bacteria in Saliva of Cancer Patients

This study examined salivary flow and salivary pH and the prevalence and levels of cariogenic bacteria in the saliva of oncological patients and healthy controls. Quantitative real-time polymerase chain reaction was used to assess the levels of microbes including Streptococcus mutans, Streptococcus...

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Autores principales: Kang, Mi-Sun, Oh, Jong-Suk, Jeong, Kyung-Yi, Kim, Hyeong-Joon, Lee, Je-Jung, Lee, Guem-Sug, Lim, Hoi-Jeong, Lim, Hae-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759686/
https://www.ncbi.nlm.nih.gov/pubmed/24010070
http://dx.doi.org/10.4068/cmj.2013.49.2.75
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author Kang, Mi-Sun
Oh, Jong-Suk
Jeong, Kyung-Yi
Kim, Hyeong-Joon
Lee, Je-Jung
Lee, Guem-Sug
Lim, Hoi-Jeong
Lim, Hae-Soon
author_facet Kang, Mi-Sun
Oh, Jong-Suk
Jeong, Kyung-Yi
Kim, Hyeong-Joon
Lee, Je-Jung
Lee, Guem-Sug
Lim, Hoi-Jeong
Lim, Hae-Soon
author_sort Kang, Mi-Sun
collection PubMed
description This study examined salivary flow and salivary pH and the prevalence and levels of cariogenic bacteria in the saliva of oncological patients and healthy controls. Quantitative real-time polymerase chain reaction was used to assess the levels of microbes including Streptococcus mutans, Streptococcus sobrinus, Lactobacillus salivarius, and Lactobacillus acidophilus in the saliva of 41 patients with a solid tumor (SO), 30 patients with a hematologic malignancy (HE), and 40 healthy controls. Salivary flow and pH were lower in oncological patients than in controls. The frequencies of all four cariogenic bacteria were highest in the SO group. S. mutans and L. salivarius were the most commonly detected in all three study groups. Mean numbers of S. sobrinus and L. salivarius in the SO group were significantly higher than in controls (p<0.05). There were no significant differences between patients and controls with respect to mean numbers of S. mutans and L. acidophilus in saliva. However, the proportions of S. mutans, S. sobrinus, and L. salivarius versus total bacteria in the SO group were significantly higher than in controls. Within patients, both mean numbers and the proportions of S. mutans and S. sobrinus were significantly different (p<0.05). In summary, significant differences were found in salivary pH values and the levels of S. mutans, S. sobrinus, and L. salivarius between SO patients and healthy controls.
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spelling pubmed-37596862013-09-04 Analysis of Cariogenic Bacteria in Saliva of Cancer Patients Kang, Mi-Sun Oh, Jong-Suk Jeong, Kyung-Yi Kim, Hyeong-Joon Lee, Je-Jung Lee, Guem-Sug Lim, Hoi-Jeong Lim, Hae-Soon Chonnam Med J Original Article This study examined salivary flow and salivary pH and the prevalence and levels of cariogenic bacteria in the saliva of oncological patients and healthy controls. Quantitative real-time polymerase chain reaction was used to assess the levels of microbes including Streptococcus mutans, Streptococcus sobrinus, Lactobacillus salivarius, and Lactobacillus acidophilus in the saliva of 41 patients with a solid tumor (SO), 30 patients with a hematologic malignancy (HE), and 40 healthy controls. Salivary flow and pH were lower in oncological patients than in controls. The frequencies of all four cariogenic bacteria were highest in the SO group. S. mutans and L. salivarius were the most commonly detected in all three study groups. Mean numbers of S. sobrinus and L. salivarius in the SO group were significantly higher than in controls (p<0.05). There were no significant differences between patients and controls with respect to mean numbers of S. mutans and L. acidophilus in saliva. However, the proportions of S. mutans, S. sobrinus, and L. salivarius versus total bacteria in the SO group were significantly higher than in controls. Within patients, both mean numbers and the proportions of S. mutans and S. sobrinus were significantly different (p<0.05). In summary, significant differences were found in salivary pH values and the levels of S. mutans, S. sobrinus, and L. salivarius between SO patients and healthy controls. Chonnam National University Medical School 2013-08 2013-08-22 /pmc/articles/PMC3759686/ /pubmed/24010070 http://dx.doi.org/10.4068/cmj.2013.49.2.75 Text en © Chonnam Medical Journal, 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kang, Mi-Sun
Oh, Jong-Suk
Jeong, Kyung-Yi
Kim, Hyeong-Joon
Lee, Je-Jung
Lee, Guem-Sug
Lim, Hoi-Jeong
Lim, Hae-Soon
Analysis of Cariogenic Bacteria in Saliva of Cancer Patients
title Analysis of Cariogenic Bacteria in Saliva of Cancer Patients
title_full Analysis of Cariogenic Bacteria in Saliva of Cancer Patients
title_fullStr Analysis of Cariogenic Bacteria in Saliva of Cancer Patients
title_full_unstemmed Analysis of Cariogenic Bacteria in Saliva of Cancer Patients
title_short Analysis of Cariogenic Bacteria in Saliva of Cancer Patients
title_sort analysis of cariogenic bacteria in saliva of cancer patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759686/
https://www.ncbi.nlm.nih.gov/pubmed/24010070
http://dx.doi.org/10.4068/cmj.2013.49.2.75
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