Chromatin targeting drugs in cancer and immunity

Recent advances in the enzymology of transcription and chromatin regulation have led to the discovery of proteins that play a prominent role in cell differentiation and the maintenance of specialized cell functions. Knowledge about post-synthetic DNA and histone modifications as well as information...

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Detalles Bibliográficos
Autores principales: Prinjha, Rab, Tarakhovsky, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759691/
https://www.ncbi.nlm.nih.gov/pubmed/23964091
http://dx.doi.org/10.1101/gad.221895.113
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author Prinjha, Rab
Tarakhovsky, Alexander
author_facet Prinjha, Rab
Tarakhovsky, Alexander
author_sort Prinjha, Rab
collection PubMed
description Recent advances in the enzymology of transcription and chromatin regulation have led to the discovery of proteins that play a prominent role in cell differentiation and the maintenance of specialized cell functions. Knowledge about post-synthetic DNA and histone modifications as well as information about the rules that guide the formation of multimolecular chromatin-bound complexes have helped to delineate gene-regulating pathways and describe how these pathways are altered in various pathological conditions. The present review focuses on the emerging area of therapeutic interference with chromatin function for the purpose of cancer treatment and immunomodulation.
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spelling pubmed-37596912014-02-15 Chromatin targeting drugs in cancer and immunity Prinjha, Rab Tarakhovsky, Alexander Genes Dev Review Recent advances in the enzymology of transcription and chromatin regulation have led to the discovery of proteins that play a prominent role in cell differentiation and the maintenance of specialized cell functions. Knowledge about post-synthetic DNA and histone modifications as well as information about the rules that guide the formation of multimolecular chromatin-bound complexes have helped to delineate gene-regulating pathways and describe how these pathways are altered in various pathological conditions. The present review focuses on the emerging area of therapeutic interference with chromatin function for the purpose of cancer treatment and immunomodulation. Cold Spring Harbor Laboratory Press 2013-08-15 /pmc/articles/PMC3759691/ /pubmed/23964091 http://dx.doi.org/10.1101/gad.221895.113 Text en © 2013, Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.
spellingShingle Review
Prinjha, Rab
Tarakhovsky, Alexander
Chromatin targeting drugs in cancer and immunity
title Chromatin targeting drugs in cancer and immunity
title_full Chromatin targeting drugs in cancer and immunity
title_fullStr Chromatin targeting drugs in cancer and immunity
title_full_unstemmed Chromatin targeting drugs in cancer and immunity
title_short Chromatin targeting drugs in cancer and immunity
title_sort chromatin targeting drugs in cancer and immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759691/
https://www.ncbi.nlm.nih.gov/pubmed/23964091
http://dx.doi.org/10.1101/gad.221895.113
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AT tarakhovskyalexander chromatintargetingdrugsincancerandimmunity

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