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E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells

Programmed mutagenesis of the immunoglobulin locus of B lymphocytes during class switch recombination (CSR) and somatic hypermutation requires RNA polymerase II (polII) transcription complex-dependent targeting of the DNA mutator activation-induced cytidine deaminase (AID). AID deaminates cytidine r...

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Detalles Bibliográficos
Autores principales:	Sun, Jianbo, Keim, Celia D., Wang, Jiguang, Kazadi, David, Oliver, Paula M., Rabadan, Raul, Basu, Uttiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759698/ https://www.ncbi.nlm.nih.gov/pubmed/23964096 http://dx.doi.org/10.1101/gad.210211.112

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