Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

Somatic mutations in kinase genes are associated with sensitivity of solid tumors to kinase inhibitors, but patients with metastatic cancer eventually develop disease progression. In EGFR mutant lung cancer, modeling of acquired resistance (AR) with drug-sensitive cell lines has identified clinicall...

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Detalles Bibliográficos
Autores principales: Jia, Peilin, Jin, Hailing, Meador, Catherine B., Xia, Junfeng, Ohashi, Kadoaki, Liu, Lin, Pirazzoli, Valentina, Dahlman, Kimberly B., Politi, Katerina, Michor, Franziska, Zhao, Zhongming, Pao, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759720/
https://www.ncbi.nlm.nih.gov/pubmed/23733853
http://dx.doi.org/10.1101/gr.152322.112

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