CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tum...

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Detalles Bibliográficos
Autores principales: Ling, Hui, Spizzo, Riccardo, Atlasi, Yaser, Nicoloso, Milena, Shimizu, Masayoshi, Redis, Roxana S., Nishida, Naohiro, Gafà, Roberta, Song, Jian, Guo, Zhiyi, Ivan, Cristina, Barbarotto, Elisa, De Vries, Ingrid, Zhang, Xinna, Ferracin, Manuela, Churchman, Mike, van Galen, Janneke F., Beverloo, Berna H., Shariati, Maryam, Haderk, Franziska, Estecio, Marcos R., Garcia-Manero, Guillermo, Patijn, Gijs A., Gotley, David C., Bhardwaj, Vikas, Shureiqi, Imad, Sen, Subrata, Multani, Asha S., Welsh, James, Yamamoto, Ken, Taniguchi, Itsuki, Song, Min-Ae, Gallinger, Steven, Casey, Graham, Thibodeau, Stephen N., Le Marchand, Loïc, Tiirikainen, Maarit, Mani, Sendurai A., Zhang, Wei, Davuluri, Ramana V., Mimori, Koshi, Mori, Masaki, Sieuwerts, Anieta M., Martens, John W.M., Tomlinson, Ian, Negrini, Massimo, Berindan-Neagoe, Ioana, Foekens, John A., Hamilton, Stanley R., Lanza, Giovanni, Kopetz, Scott, Fodde, Riccardo, Calin, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759721/
https://www.ncbi.nlm.nih.gov/pubmed/23796952
http://dx.doi.org/10.1101/gr.152942.112

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