Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs

MGH2.1 is a herpes simplex virus type 1 (HSV1) oncolytic virus that expresses two prodrug-activating transgenes: the cyclophosphamide (CPA)-activating cytochrome P4502B1 (CYP2B1) and the CPT11-activating secreted human intestinal carboxylesterase (shiCE). Toxicology and biodistribution of MGH2.1 in...

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Detalles Bibliográficos
Autores principales: Kasai, Kazue, Nakashima, Hiroshi, Liu, Fang, Kerr, Samantha, Wang, Jiang, Phelps, Mitch, Potter, Philip M, Goins, William B, Fernandez, Soledad A, Chiocca, E Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Methods - Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759737/
https://www.ncbi.nlm.nih.gov/pubmed/23922029
http://dx.doi.org/10.1038/mtna.2013.38

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