Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA. First generation AMOs employed 2′-O-Methyl RNA nucleotides (2′OMe) with phosphorothioate (PS) internucleotide linkages pos...

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Detalles Bibliográficos
Autores principales: Lennox, Kim A, Owczarzy, Richard, Thomas, Derek M, Walder, Joseph A, Behlke, Mark A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759741/
https://www.ncbi.nlm.nih.gov/pubmed/23982190
http://dx.doi.org/10.1038/mtna.2013.46

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