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Different Forms of Ghrelin Exhibit Distinct Biological Roles in Tilapia

Ghrelin has been identified in all vertebrate classes, including sharks. Each species possesses multiple forms of ghrelin that vary in peptide length and acyl modifications (e.g., n-hexanoic, n-non-anoic, n-octanoic, and n-decanoic acids) including des-acyl ghrelin. Octanoylated ghrelin has been sho...

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Autor principal: Riley, Larry G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759782/
https://www.ncbi.nlm.nih.gov/pubmed/24027561
http://dx.doi.org/10.3389/fendo.2013.00118
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author Riley, Larry G.
author_facet Riley, Larry G.
author_sort Riley, Larry G.
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description Ghrelin has been identified in all vertebrate classes, including sharks. Each species possesses multiple forms of ghrelin that vary in peptide length and acyl modifications (e.g., n-hexanoic, n-non-anoic, n-octanoic, and n-decanoic acids) including des-acyl ghrelin. Octanoylated ghrelin has been shown to be a potent GH secretagogue, orexigenic factor, and plays a role in overall metabolism in vertebrates. In the tilapia model, octanoylated ghrelin (ghrelin-C8) and decanoylated ghrelin (ghrelin-C10) exhibit different biological actions. This mini review highlights the current knowledge of the differential actions of ghrelin-C8 and ghrelin-C10 from studies in the tilapia model. These findings suggest that the multiple forms of ghrelin may exhibit distinct yet complimentary actions directed toward maintaining overall energy balance in other vertebrates.
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spelling pubmed-37597822013-09-11 Different Forms of Ghrelin Exhibit Distinct Biological Roles in Tilapia Riley, Larry G. Front Endocrinol (Lausanne) Endocrinology Ghrelin has been identified in all vertebrate classes, including sharks. Each species possesses multiple forms of ghrelin that vary in peptide length and acyl modifications (e.g., n-hexanoic, n-non-anoic, n-octanoic, and n-decanoic acids) including des-acyl ghrelin. Octanoylated ghrelin has been shown to be a potent GH secretagogue, orexigenic factor, and plays a role in overall metabolism in vertebrates. In the tilapia model, octanoylated ghrelin (ghrelin-C8) and decanoylated ghrelin (ghrelin-C10) exhibit different biological actions. This mini review highlights the current knowledge of the differential actions of ghrelin-C8 and ghrelin-C10 from studies in the tilapia model. These findings suggest that the multiple forms of ghrelin may exhibit distinct yet complimentary actions directed toward maintaining overall energy balance in other vertebrates. Frontiers Media S.A. 2013-09-03 /pmc/articles/PMC3759782/ /pubmed/24027561 http://dx.doi.org/10.3389/fendo.2013.00118 Text en Copyright © 2013 Riley. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Riley, Larry G.
Different Forms of Ghrelin Exhibit Distinct Biological Roles in Tilapia
title Different Forms of Ghrelin Exhibit Distinct Biological Roles in Tilapia
title_full Different Forms of Ghrelin Exhibit Distinct Biological Roles in Tilapia
title_fullStr Different Forms of Ghrelin Exhibit Distinct Biological Roles in Tilapia
title_full_unstemmed Different Forms of Ghrelin Exhibit Distinct Biological Roles in Tilapia
title_short Different Forms of Ghrelin Exhibit Distinct Biological Roles in Tilapia
title_sort different forms of ghrelin exhibit distinct biological roles in tilapia
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759782/
https://www.ncbi.nlm.nih.gov/pubmed/24027561
http://dx.doi.org/10.3389/fendo.2013.00118
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