Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation

Pgrmc1 (progesterone receptor membrane component 1) is a multifunctional 22 kDa protein with heme-binding and P450-activating capacity which was recognized under different names for roles in cell motility during neural development and in cancer, and apoptosis. Pgrmc1 expression in microglia was rece...

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Detalles Bibliográficos
Autores principales: Bali, N., Morgan, T. E., Finch, C. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759828/
https://www.ncbi.nlm.nih.gov/pubmed/24027494
http://dx.doi.org/10.3389/fnins.2013.00157
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author Bali, N.
Morgan, T. E.
Finch, C. E.
author_facet Bali, N.
Morgan, T. E.
Finch, C. E.
author_sort Bali, N.
collection PubMed
description Pgrmc1 (progesterone receptor membrane component 1) is a multifunctional 22 kDa protein with heme-binding and P450-activating capacity which was recognized under different names for roles in cell motility during neural development and in cancer, and apoptosis. Pgrmc1 expression in microglia was recently shown by the present authors to mediate estrogen-progesterone interactions during axonal sprouting and to mediate microglial activation itself. We also discuss other functions of Pgramc1 in the nervous system and its possible relationship to the 18 kDa sigma-2 receptor (S2R).
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spelling pubmed-37598282013-09-11 Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation Bali, N. Morgan, T. E. Finch, C. E. Front Neurosci Endocrinology Pgrmc1 (progesterone receptor membrane component 1) is a multifunctional 22 kDa protein with heme-binding and P450-activating capacity which was recognized under different names for roles in cell motility during neural development and in cancer, and apoptosis. Pgrmc1 expression in microglia was recently shown by the present authors to mediate estrogen-progesterone interactions during axonal sprouting and to mediate microglial activation itself. We also discuss other functions of Pgramc1 in the nervous system and its possible relationship to the 18 kDa sigma-2 receptor (S2R). Frontiers Media S.A. 2013-09-03 /pmc/articles/PMC3759828/ /pubmed/24027494 http://dx.doi.org/10.3389/fnins.2013.00157 Text en Copyright © 2013 Bali, Morgan and Finch. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Bali, N.
Morgan, T. E.
Finch, C. E.
Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation
title Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation
title_full Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation
title_fullStr Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation
title_full_unstemmed Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation
title_short Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation
title_sort pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759828/
https://www.ncbi.nlm.nih.gov/pubmed/24027494
http://dx.doi.org/10.3389/fnins.2013.00157
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AT finchce pgrmc1newrolesinthemicroglialmediationofprogesteroneantagonismofestradioldependentneuritesproutingandinmicroglialactivation

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