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S-Glutathionylation in Monocyte and Macrophage (Dys)Function

Atherosclerosis is a chronic inflammatory disease involving the accumulation of monocytes and macrophages in the vascular wall. Monocytes and macrophages play a central role in the initiation and progression of atherosclerotic lesion development. Oxidative stress, which occurs when reactive oxygen s...

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Detalles Bibliográficos
Autores principales: Ullevig, Sarah, Kim, Hong Seok, Asmis, Reto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759857/
https://www.ncbi.nlm.nih.gov/pubmed/23887649
http://dx.doi.org/10.3390/ijms140815212
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author Ullevig, Sarah
Kim, Hong Seok
Asmis, Reto
author_facet Ullevig, Sarah
Kim, Hong Seok
Asmis, Reto
author_sort Ullevig, Sarah
collection PubMed
description Atherosclerosis is a chronic inflammatory disease involving the accumulation of monocytes and macrophages in the vascular wall. Monocytes and macrophages play a central role in the initiation and progression of atherosclerotic lesion development. Oxidative stress, which occurs when reactive oxygen species (ROS) overwhelm cellular antioxidant systems, contributes to the pathophysiology of many chronic inflammatory diseases, including atherosclerosis. Major targets of ROS are reactive thiols on cysteine residues in proteins, which when oxidized can alter cellular processes, including signaling pathways, metabolic pathways, transcription, and translation. Protein-S-glutathionylation is the process of mixed disulfide formation between glutathione (GSH) and protein thiols. Until recently, protein-S-glutathionylation was associated with increased cellular oxidative stress, but S-glutathionylation of key protein targets has now emerged as a physiologically important redox signaling mechanism, which when dysregulated contributes to a variety of disease processes. In this review, we will explore the role of thiol oxidative stress and protein-S-glutathionylation in monocyte and macrophage dysfunction as a mechanistic link between oxidative stress associated with metabolic disorders and chronic inflammatory diseases, including atherosclerosis.
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spelling pubmed-37598572013-09-03 S-Glutathionylation in Monocyte and Macrophage (Dys)Function Ullevig, Sarah Kim, Hong Seok Asmis, Reto Int J Mol Sci Review Atherosclerosis is a chronic inflammatory disease involving the accumulation of monocytes and macrophages in the vascular wall. Monocytes and macrophages play a central role in the initiation and progression of atherosclerotic lesion development. Oxidative stress, which occurs when reactive oxygen species (ROS) overwhelm cellular antioxidant systems, contributes to the pathophysiology of many chronic inflammatory diseases, including atherosclerosis. Major targets of ROS are reactive thiols on cysteine residues in proteins, which when oxidized can alter cellular processes, including signaling pathways, metabolic pathways, transcription, and translation. Protein-S-glutathionylation is the process of mixed disulfide formation between glutathione (GSH) and protein thiols. Until recently, protein-S-glutathionylation was associated with increased cellular oxidative stress, but S-glutathionylation of key protein targets has now emerged as a physiologically important redox signaling mechanism, which when dysregulated contributes to a variety of disease processes. In this review, we will explore the role of thiol oxidative stress and protein-S-glutathionylation in monocyte and macrophage dysfunction as a mechanistic link between oxidative stress associated with metabolic disorders and chronic inflammatory diseases, including atherosclerosis. MDPI 2013-07-24 /pmc/articles/PMC3759857/ /pubmed/23887649 http://dx.doi.org/10.3390/ijms140815212 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Ullevig, Sarah
Kim, Hong Seok
Asmis, Reto
S-Glutathionylation in Monocyte and Macrophage (Dys)Function
title S-Glutathionylation in Monocyte and Macrophage (Dys)Function
title_full S-Glutathionylation in Monocyte and Macrophage (Dys)Function
title_fullStr S-Glutathionylation in Monocyte and Macrophage (Dys)Function
title_full_unstemmed S-Glutathionylation in Monocyte and Macrophage (Dys)Function
title_short S-Glutathionylation in Monocyte and Macrophage (Dys)Function
title_sort s-glutathionylation in monocyte and macrophage (dys)function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759857/
https://www.ncbi.nlm.nih.gov/pubmed/23887649
http://dx.doi.org/10.3390/ijms140815212
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