Exploring the Glycosylation of Serum CA125

Ovarian cancer is the most lethal gynaecologic cancer affecting women. The most widely used biomarker for ovarian cancer, CA125, lacks sensitivity and specificity. Here, we explored differences in glycosylation of CA125 between serum from patients with ovarian cancer and healthy controls. We found d...

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Detalles Bibliográficos
Autores principales: Saldova, Radka, Struwe, Weston B., Wynne, Kieran, Elia, Giuliano, Duffy, Michael J., Rudd, Pauline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759877/
https://www.ncbi.nlm.nih.gov/pubmed/23896595
http://dx.doi.org/10.3390/ijms140815636
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author Saldova, Radka
Struwe, Weston B.
Wynne, Kieran
Elia, Giuliano
Duffy, Michael J.
Rudd, Pauline M.
author_facet Saldova, Radka
Struwe, Weston B.
Wynne, Kieran
Elia, Giuliano
Duffy, Michael J.
Rudd, Pauline M.
author_sort Saldova, Radka
collection PubMed
description Ovarian cancer is the most lethal gynaecologic cancer affecting women. The most widely used biomarker for ovarian cancer, CA125, lacks sensitivity and specificity. Here, we explored differences in glycosylation of CA125 between serum from patients with ovarian cancer and healthy controls. We found differences between CA125 N-glycans from patient sera compared to controls. These include increases in core-fucosylated bi-antennary monosialylated glycans, as well as decreases in mostly bisecting bi-antennary and non-fucosylated glycans in patients compared to controls. Measurement of the glycosylated state of CA125 may therefore provide a more specific biomarker for patients with ovarian cancer.
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spelling pubmed-37598772013-09-03 Exploring the Glycosylation of Serum CA125 Saldova, Radka Struwe, Weston B. Wynne, Kieran Elia, Giuliano Duffy, Michael J. Rudd, Pauline M. Int J Mol Sci Article Ovarian cancer is the most lethal gynaecologic cancer affecting women. The most widely used biomarker for ovarian cancer, CA125, lacks sensitivity and specificity. Here, we explored differences in glycosylation of CA125 between serum from patients with ovarian cancer and healthy controls. We found differences between CA125 N-glycans from patient sera compared to controls. These include increases in core-fucosylated bi-antennary monosialylated glycans, as well as decreases in mostly bisecting bi-antennary and non-fucosylated glycans in patients compared to controls. Measurement of the glycosylated state of CA125 may therefore provide a more specific biomarker for patients with ovarian cancer. Molecular Diversity Preservation International (MDPI) 2013-07-26 /pmc/articles/PMC3759877/ /pubmed/23896595 http://dx.doi.org/10.3390/ijms140815636 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Saldova, Radka
Struwe, Weston B.
Wynne, Kieran
Elia, Giuliano
Duffy, Michael J.
Rudd, Pauline M.
Exploring the Glycosylation of Serum CA125
title Exploring the Glycosylation of Serum CA125
title_full Exploring the Glycosylation of Serum CA125
title_fullStr Exploring the Glycosylation of Serum CA125
title_full_unstemmed Exploring the Glycosylation of Serum CA125
title_short Exploring the Glycosylation of Serum CA125
title_sort exploring the glycosylation of serum ca125
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759877/
https://www.ncbi.nlm.nih.gov/pubmed/23896595
http://dx.doi.org/10.3390/ijms140815636
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