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Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer
Ovarian Cancer represents the most fatal type of gynecological malignancies. A number of processes are involved in the pathogenesis of ovarian cancer, especially within the tumor microenvironment. Angiogenesis represents a hallmark phenomenon in cancer, and it is responsible for tumor spread and met...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759892/ https://www.ncbi.nlm.nih.gov/pubmed/23903048 http://dx.doi.org/10.3390/ijms140815885 |
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author | Gavalas, Nikos G. Liontos, Michalis Trachana, Sofia-Paraskevi Bagratuni, Tina Arapinis, Calliope Liacos, Christine Dimopoulos, Meletios A. Bamias, Aristotle |
author_facet | Gavalas, Nikos G. Liontos, Michalis Trachana, Sofia-Paraskevi Bagratuni, Tina Arapinis, Calliope Liacos, Christine Dimopoulos, Meletios A. Bamias, Aristotle |
author_sort | Gavalas, Nikos G. |
collection | PubMed |
description | Ovarian Cancer represents the most fatal type of gynecological malignancies. A number of processes are involved in the pathogenesis of ovarian cancer, especially within the tumor microenvironment. Angiogenesis represents a hallmark phenomenon in cancer, and it is responsible for tumor spread and metastasis in ovarian cancer, among other tumor types, as it leads to new blood vessel formation. In recent years angiogenesis has been given considerable attention in order to identify targets for developing effective anti-tumor therapies. Growth factors have been identified to play key roles in driving angiogenesis and, thus, the formation of new blood vessels that assist in “feeding” cancer. Such molecules include the vascular endothelial growth factor (VEGF), the platelet derived growth factor (PDGF), the fibroblast growth factor (FGF), and the angiopoietin/Tie2 receptor complex. These proteins are key players in complex molecular pathways within the tumor cell and they have been in the spotlight of the development of anti-angiogenic molecules that may act as stand-alone therapeutics, or in concert with standard treatment regimes such as chemotherapy. The pathways involved in angiogenesis and molecules that have been developed in order to combat angiogenesis are described in this paper. |
format | Online Article Text |
id | pubmed-3759892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37598922013-09-03 Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer Gavalas, Nikos G. Liontos, Michalis Trachana, Sofia-Paraskevi Bagratuni, Tina Arapinis, Calliope Liacos, Christine Dimopoulos, Meletios A. Bamias, Aristotle Int J Mol Sci Review Ovarian Cancer represents the most fatal type of gynecological malignancies. A number of processes are involved in the pathogenesis of ovarian cancer, especially within the tumor microenvironment. Angiogenesis represents a hallmark phenomenon in cancer, and it is responsible for tumor spread and metastasis in ovarian cancer, among other tumor types, as it leads to new blood vessel formation. In recent years angiogenesis has been given considerable attention in order to identify targets for developing effective anti-tumor therapies. Growth factors have been identified to play key roles in driving angiogenesis and, thus, the formation of new blood vessels that assist in “feeding” cancer. Such molecules include the vascular endothelial growth factor (VEGF), the platelet derived growth factor (PDGF), the fibroblast growth factor (FGF), and the angiopoietin/Tie2 receptor complex. These proteins are key players in complex molecular pathways within the tumor cell and they have been in the spotlight of the development of anti-angiogenic molecules that may act as stand-alone therapeutics, or in concert with standard treatment regimes such as chemotherapy. The pathways involved in angiogenesis and molecules that have been developed in order to combat angiogenesis are described in this paper. Molecular Diversity Preservation International (MDPI) 2013-07-30 /pmc/articles/PMC3759892/ /pubmed/23903048 http://dx.doi.org/10.3390/ijms140815885 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Gavalas, Nikos G. Liontos, Michalis Trachana, Sofia-Paraskevi Bagratuni, Tina Arapinis, Calliope Liacos, Christine Dimopoulos, Meletios A. Bamias, Aristotle Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer |
title | Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer |
title_full | Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer |
title_fullStr | Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer |
title_full_unstemmed | Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer |
title_short | Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer |
title_sort | angiogenesis-related pathways in the pathogenesis of ovarian cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759892/ https://www.ncbi.nlm.nih.gov/pubmed/23903048 http://dx.doi.org/10.3390/ijms140815885 |
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