Principles of miRNA-Target Regulation in Metazoan Models

MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to var...

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Detalles Bibliográficos
Autor principal: Doxakis, Epaminondas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759911/
https://www.ncbi.nlm.nih.gov/pubmed/23965954
http://dx.doi.org/10.3390/ijms140816280
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author Doxakis, Epaminondas
author_facet Doxakis, Epaminondas
author_sort Doxakis, Epaminondas
collection PubMed
description MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged.
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spelling pubmed-37599112013-09-03 Principles of miRNA-Target Regulation in Metazoan Models Doxakis, Epaminondas Int J Mol Sci Review MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged. Molecular Diversity Preservation International (MDPI) 2013-08-07 /pmc/articles/PMC3759911/ /pubmed/23965954 http://dx.doi.org/10.3390/ijms140816280 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Doxakis, Epaminondas
Principles of miRNA-Target Regulation in Metazoan Models
title Principles of miRNA-Target Regulation in Metazoan Models
title_full Principles of miRNA-Target Regulation in Metazoan Models
title_fullStr Principles of miRNA-Target Regulation in Metazoan Models
title_full_unstemmed Principles of miRNA-Target Regulation in Metazoan Models
title_short Principles of miRNA-Target Regulation in Metazoan Models
title_sort principles of mirna-target regulation in metazoan models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759911/
https://www.ncbi.nlm.nih.gov/pubmed/23965954
http://dx.doi.org/10.3390/ijms140816280
work_keys_str_mv AT doxakisepaminondas principlesofmirnatargetregulationinmetazoanmodels

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