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Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate intoxication. Standard care involves the use of anticonvulsants (e.g., diazepam), parasympatolytics (e.g., atropine) and oximes that restore AChE activity. However, oximes also bind to the active site of ACh...

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Detalles Bibliográficos
Autores principales:	Sepsova, Vendula, Karasova, Jana Zdarova, Korabecny, Jan, Dolezal, Rafael, Zemek, Filip, Bennion, Brian J., Kuca, Kamil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759941/ https://www.ncbi.nlm.nih.gov/pubmed/23959117 http://dx.doi.org/10.3390/ijms140816882

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