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Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines

Plant-derived polyphenols are being tested as chemopreventive agents; some polyphenols arrest the cell cycle at G1 phase, whereas others inhibit cell cycle proliferation at G2/M phase. Therefore, polyphenols have been proposed to inhibit cell cycle progression at different phases via distinct mechan...

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Autores principales: Shin, Soon Young, Yoon, Hyuk, Ahn, Seunghyun, Kim, Dong-Wook, Bae, Dong-Ho, Koh, Dongsoo, Lee, Young Han, Lim, Yoongho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759946/
https://www.ncbi.nlm.nih.gov/pubmed/23965967
http://dx.doi.org/10.3390/ijms140816970
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author Shin, Soon Young
Yoon, Hyuk
Ahn, Seunghyun
Kim, Dong-Wook
Bae, Dong-Ho
Koh, Dongsoo
Lee, Young Han
Lim, Yoongho
author_facet Shin, Soon Young
Yoon, Hyuk
Ahn, Seunghyun
Kim, Dong-Wook
Bae, Dong-Ho
Koh, Dongsoo
Lee, Young Han
Lim, Yoongho
author_sort Shin, Soon Young
collection PubMed
description Plant-derived polyphenols are being tested as chemopreventive agents; some polyphenols arrest the cell cycle at G1 phase, whereas others inhibit cell cycle proliferation at G2/M phase. Therefore, polyphenols have been proposed to inhibit cell cycle progression at different phases via distinct mechanisms. Indeed, our previous studies showed that small structural differences in polyphenols cause large differences in their biological activities; however, the details of the structural properties causing G1 cell cycle arrest remain unknown. In this study, we prepared 27 polyphenols, including eight different scaffolds, to gain insight into the structural conditions that arrest the cell cycle at G1 phase in a quantitative structure–activity relationship study. We used cell cycle profiles to determine the biophores responsible for G1 cell cycle arrest and believe that the biophores identified in this study will help design polyphenols that cause G1 cell cycle arrest.
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spelling pubmed-37599462013-09-03 Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines Shin, Soon Young Yoon, Hyuk Ahn, Seunghyun Kim, Dong-Wook Bae, Dong-Ho Koh, Dongsoo Lee, Young Han Lim, Yoongho Int J Mol Sci Article Plant-derived polyphenols are being tested as chemopreventive agents; some polyphenols arrest the cell cycle at G1 phase, whereas others inhibit cell cycle proliferation at G2/M phase. Therefore, polyphenols have been proposed to inhibit cell cycle progression at different phases via distinct mechanisms. Indeed, our previous studies showed that small structural differences in polyphenols cause large differences in their biological activities; however, the details of the structural properties causing G1 cell cycle arrest remain unknown. In this study, we prepared 27 polyphenols, including eight different scaffolds, to gain insight into the structural conditions that arrest the cell cycle at G1 phase in a quantitative structure–activity relationship study. We used cell cycle profiles to determine the biophores responsible for G1 cell cycle arrest and believe that the biophores identified in this study will help design polyphenols that cause G1 cell cycle arrest. Molecular Diversity Preservation International (MDPI) 2013-08-19 /pmc/articles/PMC3759946/ /pubmed/23965967 http://dx.doi.org/10.3390/ijms140816970 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Shin, Soon Young
Yoon, Hyuk
Ahn, Seunghyun
Kim, Dong-Wook
Bae, Dong-Ho
Koh, Dongsoo
Lee, Young Han
Lim, Yoongho
Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines
title Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines
title_full Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines
title_fullStr Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines
title_full_unstemmed Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines
title_short Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines
title_sort structural properties of polyphenols causing cell cycle arrest at g1 phase in hct116 human colorectal cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759946/
https://www.ncbi.nlm.nih.gov/pubmed/23965967
http://dx.doi.org/10.3390/ijms140816970
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