Effects of Decreased Vitamin D and Accumulated Uremic Toxin on Human CYP3A4 Activity in Patients with End-Stage Renal Disease

In patients with end-stage renal disease, not only renal clearance but also hepatic clearance is known to be impaired. For instance, the concentration of erythromycin, a substrate of cytochrome P450 3A4 (CYP3A4), has been reported to be elevated in patients with end-stage renal disease. The purpose...

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Detalles Bibliográficos
Autores principales: Tsujimoto, Masayuki, Nagano, Yui, Hosoda, Satomi, Shiraishi, Asuka, Miyoshi, Ayaka, Hiraoka, Shima, Furukubo, Taku, Izumi, Satoshi, Yamakawa, Tomoyuki, Minegaki, Tetsuya, Nishiguchi, Kohshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760047/
https://www.ncbi.nlm.nih.gov/pubmed/23965431
http://dx.doi.org/10.3390/toxins5081475

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