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Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study

Evidence from clinical reports has indicated that acupuncture has a promising effect on mild cognitive impairment (MCI). However, it is still unknown that by what way acupuncture can modulate brain networks involving the MCI. In the current study, multivariate Granger causality analysis (mGCA) was a...

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Autores principales: Chen, Shangjie, Bai, Lijun, Xu, Maosheng, Wang, Fang, Yin, Liang, Peng, Xuming, Chen, Xinghua, Shi, Xuemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760118/
https://www.ncbi.nlm.nih.gov/pubmed/24023568
http://dx.doi.org/10.1155/2013/127271
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author Chen, Shangjie
Bai, Lijun
Xu, Maosheng
Wang, Fang
Yin, Liang
Peng, Xuming
Chen, Xinghua
Shi, Xuemin
author_facet Chen, Shangjie
Bai, Lijun
Xu, Maosheng
Wang, Fang
Yin, Liang
Peng, Xuming
Chen, Xinghua
Shi, Xuemin
author_sort Chen, Shangjie
collection PubMed
description Evidence from clinical reports has indicated that acupuncture has a promising effect on mild cognitive impairment (MCI). However, it is still unknown that by what way acupuncture can modulate brain networks involving the MCI. In the current study, multivariate Granger causality analysis (mGCA) was adopted to compare the interregional effective connectivity of brain networks by varying needling depths (deep acupuncture, DA; superficial acupuncture, SA) and at different cognitive states, which were the MCI and healthy control (HC). Results from DA at KI3 in MCI showed that the dorsolateral prefrontal cortex and hippocampus emerged as central hubs and had significant causal influences with each other, but significant in HC for DA. Moreover, only several brain regions had remarkable causal interactions following SA in MCI and even few brain regions following SA in HC. Our results indicated that acupuncture at KI3 at different cognitive states and with varying needling depths may induce distinct reorganizations of effective connectivities of brain networks, and DA at KI3 in MCI can induce the strongest and more extensive effective connectivities related to the therapeutic effect of acupuncture in MCI. The study demonstrated the relatively functional specificity of acupuncture at KI3 in MCI, and needling depths play an important role in acupuncture treatments.
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spelling pubmed-37601182013-09-10 Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study Chen, Shangjie Bai, Lijun Xu, Maosheng Wang, Fang Yin, Liang Peng, Xuming Chen, Xinghua Shi, Xuemin Evid Based Complement Alternat Med Research Article Evidence from clinical reports has indicated that acupuncture has a promising effect on mild cognitive impairment (MCI). However, it is still unknown that by what way acupuncture can modulate brain networks involving the MCI. In the current study, multivariate Granger causality analysis (mGCA) was adopted to compare the interregional effective connectivity of brain networks by varying needling depths (deep acupuncture, DA; superficial acupuncture, SA) and at different cognitive states, which were the MCI and healthy control (HC). Results from DA at KI3 in MCI showed that the dorsolateral prefrontal cortex and hippocampus emerged as central hubs and had significant causal influences with each other, but significant in HC for DA. Moreover, only several brain regions had remarkable causal interactions following SA in MCI and even few brain regions following SA in HC. Our results indicated that acupuncture at KI3 at different cognitive states and with varying needling depths may induce distinct reorganizations of effective connectivities of brain networks, and DA at KI3 in MCI can induce the strongest and more extensive effective connectivities related to the therapeutic effect of acupuncture in MCI. The study demonstrated the relatively functional specificity of acupuncture at KI3 in MCI, and needling depths play an important role in acupuncture treatments. Hindawi Publishing Corporation 2013 2013-08-19 /pmc/articles/PMC3760118/ /pubmed/24023568 http://dx.doi.org/10.1155/2013/127271 Text en Copyright © 2013 Shangjie Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Shangjie
Bai, Lijun
Xu, Maosheng
Wang, Fang
Yin, Liang
Peng, Xuming
Chen, Xinghua
Shi, Xuemin
Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study
title Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study
title_full Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study
title_fullStr Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study
title_full_unstemmed Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study
title_short Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study
title_sort multivariate granger causality analysis of acupuncture effects in mild cognitive impairment patients: an fmri study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760118/
https://www.ncbi.nlm.nih.gov/pubmed/24023568
http://dx.doi.org/10.1155/2013/127271
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