Cargando…
Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma
Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the efficacy of platinum-paclitaxel treatment in patients with primary epithelial ovarian carcinoma, platinum-based chemotherapy is not curative and resistance remains one of the most important causes of treatmen...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760178/ https://www.ncbi.nlm.nih.gov/pubmed/24024181 http://dx.doi.org/10.1155/2013/143202 |
_version_ | 1782282740179140608 |
---|---|
author | Bagnoli, Marina Beretta, Giovanni L. Gatti, Laura Pilotti, Silvana Alberti, Paola Tarantino, Eva Barbareschi, Mattia Canevari, Silvana Mezzanzanica, Delia Perego, Paola |
author_facet | Bagnoli, Marina Beretta, Giovanni L. Gatti, Laura Pilotti, Silvana Alberti, Paola Tarantino, Eva Barbareschi, Mattia Canevari, Silvana Mezzanzanica, Delia Perego, Paola |
author_sort | Bagnoli, Marina |
collection | PubMed |
description | Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the efficacy of platinum-paclitaxel treatment in patients with primary epithelial ovarian carcinoma, platinum-based chemotherapy is not curative and resistance remains one of the most important causes of treatment failure. Although ABC transporters have been implicated in cellular resistance to multiple drugs, the clinical relevance of these efflux pumps is still poorly understood. Thus, we examined the prognostic role of transporters of the MRP family (i.e., ABCC1/MRP1, ABCC4/MRP4) to gain insights into their clinical impacts. A case material of 127 patients with ovarian carcinoma at different stages and histotypes was used. The expression of MRP1 and MRP4 was examined by immunohistochemistry using tissue microarrays in tumor specimens collected at the time of initial surgery expression. We found an association between MRP1 expression and grading, and we observed that MRP4 displayed an unfavourable impact on disease relapse in multivariate analysis (HR = 2.05, 95% CI: 1.01–4.11; P = 0.045). These results suggest that in epithelial ovarian cancer, MRP1 may be a marker for aggressiveness because its expression was associated with tumor grade and support that MRP4 may play an unfavourable role in disease outcome. |
format | Online Article Text |
id | pubmed-3760178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37601782013-09-10 Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma Bagnoli, Marina Beretta, Giovanni L. Gatti, Laura Pilotti, Silvana Alberti, Paola Tarantino, Eva Barbareschi, Mattia Canevari, Silvana Mezzanzanica, Delia Perego, Paola Biomed Res Int Clinical Study Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the efficacy of platinum-paclitaxel treatment in patients with primary epithelial ovarian carcinoma, platinum-based chemotherapy is not curative and resistance remains one of the most important causes of treatment failure. Although ABC transporters have been implicated in cellular resistance to multiple drugs, the clinical relevance of these efflux pumps is still poorly understood. Thus, we examined the prognostic role of transporters of the MRP family (i.e., ABCC1/MRP1, ABCC4/MRP4) to gain insights into their clinical impacts. A case material of 127 patients with ovarian carcinoma at different stages and histotypes was used. The expression of MRP1 and MRP4 was examined by immunohistochemistry using tissue microarrays in tumor specimens collected at the time of initial surgery expression. We found an association between MRP1 expression and grading, and we observed that MRP4 displayed an unfavourable impact on disease relapse in multivariate analysis (HR = 2.05, 95% CI: 1.01–4.11; P = 0.045). These results suggest that in epithelial ovarian cancer, MRP1 may be a marker for aggressiveness because its expression was associated with tumor grade and support that MRP4 may play an unfavourable role in disease outcome. Hindawi Publishing Corporation 2013 2013-08-19 /pmc/articles/PMC3760178/ /pubmed/24024181 http://dx.doi.org/10.1155/2013/143202 Text en Copyright © 2013 Marina Bagnoli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Bagnoli, Marina Beretta, Giovanni L. Gatti, Laura Pilotti, Silvana Alberti, Paola Tarantino, Eva Barbareschi, Mattia Canevari, Silvana Mezzanzanica, Delia Perego, Paola Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma |
title | Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma |
title_full | Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma |
title_fullStr | Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma |
title_full_unstemmed | Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma |
title_short | Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma |
title_sort | clinicopathological impact of abcc1/mrp1 and abcc4/mrp4 in epithelial ovarian carcinoma |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760178/ https://www.ncbi.nlm.nih.gov/pubmed/24024181 http://dx.doi.org/10.1155/2013/143202 |
work_keys_str_mv | AT bagnolimarina clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT berettagiovannil clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT gattilaura clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT pilottisilvana clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT albertipaola clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT tarantinoeva clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT barbareschimattia clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT canevarisilvana clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT mezzanzanicadelia clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma AT peregopaola clinicopathologicalimpactofabcc1mrp1andabcc4mrp4inepithelialovariancarcinoma |