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Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases
Consistent evidence indicates the involvement of the brain-derived neurotrophic factor (BDNF) in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). In the present study, we compared serum BDNF in 624 subjects: 266 patients affected by AD, 28 by front...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760208/ https://www.ncbi.nlm.nih.gov/pubmed/24024214 http://dx.doi.org/10.1155/2013/901082 |
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author | Ventriglia, Mariacarla Zanardini, Roberta Bonomini, Cristina Zanetti, Orazio Volpe, Daniele Pasqualetti, Patrizio Gennarelli, Massimo Bocchio-Chiavetto, Luisella |
author_facet | Ventriglia, Mariacarla Zanardini, Roberta Bonomini, Cristina Zanetti, Orazio Volpe, Daniele Pasqualetti, Patrizio Gennarelli, Massimo Bocchio-Chiavetto, Luisella |
author_sort | Ventriglia, Mariacarla |
collection | PubMed |
description | Consistent evidence indicates the involvement of the brain-derived neurotrophic factor (BDNF) in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). In the present study, we compared serum BDNF in 624 subjects: 266 patients affected by AD, 28 by frontotemporal dementia (FTD), 40 by Lewy body dementia (LBD), 91 by vascular dementia (VAD), 30 by PD, and 169 controls. Our results evidenced lower BDNF serum levels in AD, FTD, LBD, and VAD patients (P < 0.001) and a higher BDNF concentration in patients affected by PD (P = 0.045). Analyses of effects of pharmacological treatments suggested significantly higher BDNF serum levels in patients taking mood stabilizers/antiepileptics (P = 0.009) and L-DOPA (P < 0.001) and significant reductions in patients taking benzodiazepines (P = 0.020). In conclusion, our results support the role of BDNF alterations in neurodegenerative mechanisms common to different forms of neurological disorders and underline the importance of including drug treatment in the analyses to avoid confounding effects. |
format | Online Article Text |
id | pubmed-3760208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37602082013-09-10 Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases Ventriglia, Mariacarla Zanardini, Roberta Bonomini, Cristina Zanetti, Orazio Volpe, Daniele Pasqualetti, Patrizio Gennarelli, Massimo Bocchio-Chiavetto, Luisella Biomed Res Int Research Article Consistent evidence indicates the involvement of the brain-derived neurotrophic factor (BDNF) in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). In the present study, we compared serum BDNF in 624 subjects: 266 patients affected by AD, 28 by frontotemporal dementia (FTD), 40 by Lewy body dementia (LBD), 91 by vascular dementia (VAD), 30 by PD, and 169 controls. Our results evidenced lower BDNF serum levels in AD, FTD, LBD, and VAD patients (P < 0.001) and a higher BDNF concentration in patients affected by PD (P = 0.045). Analyses of effects of pharmacological treatments suggested significantly higher BDNF serum levels in patients taking mood stabilizers/antiepileptics (P = 0.009) and L-DOPA (P < 0.001) and significant reductions in patients taking benzodiazepines (P = 0.020). In conclusion, our results support the role of BDNF alterations in neurodegenerative mechanisms common to different forms of neurological disorders and underline the importance of including drug treatment in the analyses to avoid confounding effects. Hindawi Publishing Corporation 2013 2013-08-19 /pmc/articles/PMC3760208/ /pubmed/24024214 http://dx.doi.org/10.1155/2013/901082 Text en Copyright © 2013 Mariacarla Ventriglia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ventriglia, Mariacarla Zanardini, Roberta Bonomini, Cristina Zanetti, Orazio Volpe, Daniele Pasqualetti, Patrizio Gennarelli, Massimo Bocchio-Chiavetto, Luisella Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases |
title | Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases |
title_full | Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases |
title_fullStr | Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases |
title_full_unstemmed | Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases |
title_short | Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases |
title_sort | serum brain-derived neurotrophic factor levels in different neurological diseases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760208/ https://www.ncbi.nlm.nih.gov/pubmed/24024214 http://dx.doi.org/10.1155/2013/901082 |
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