Resident viruses and their interactions with the immune system

The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota...

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Detalles Bibliográficos
Autores principales: Duerkop, Breck A, Hooper, Lora V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760236/
https://www.ncbi.nlm.nih.gov/pubmed/23778792
http://dx.doi.org/10.1038/ni.2614
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author Duerkop, Breck A
Hooper, Lora V
author_facet Duerkop, Breck A
Hooper, Lora V
author_sort Duerkop, Breck A
collection PubMed
description The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota–immune system interactions for human health.
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spelling pubmed-37602362013-09-03 Resident viruses and their interactions with the immune system Duerkop, Breck A Hooper, Lora V Nat Immunol Article The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota–immune system interactions for human health. Nature Publishing Group US 2013-06-18 2013 /pmc/articles/PMC3760236/ /pubmed/23778792 http://dx.doi.org/10.1038/ni.2614 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Duerkop, Breck A
Hooper, Lora V
Resident viruses and their interactions with the immune system
title Resident viruses and their interactions with the immune system
title_full Resident viruses and their interactions with the immune system
title_fullStr Resident viruses and their interactions with the immune system
title_full_unstemmed Resident viruses and their interactions with the immune system
title_short Resident viruses and their interactions with the immune system
title_sort resident viruses and their interactions with the immune system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760236/
https://www.ncbi.nlm.nih.gov/pubmed/23778792
http://dx.doi.org/10.1038/ni.2614
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