Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif

It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that bl...

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Detalles Bibliográficos
Autores principales: Jónsson, Stefán R., Andrésdóttir, Valgerdur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761234/
https://www.ncbi.nlm.nih.gov/pubmed/23903287
http://dx.doi.org/10.3390/v5081934
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author Jónsson, Stefán R.
Andrésdóttir, Valgerdur
author_facet Jónsson, Stefán R.
Andrésdóttir, Valgerdur
author_sort Jónsson, Stefán R.
collection PubMed
description It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif.
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spelling pubmed-37612342013-09-04 Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif Jónsson, Stefán R. Andrésdóttir, Valgerdur Viruses Review It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif. MDPI 2013-07-30 /pmc/articles/PMC3761234/ /pubmed/23903287 http://dx.doi.org/10.3390/v5081934 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Jónsson, Stefán R.
Andrésdóttir, Valgerdur
Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
title Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
title_full Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
title_fullStr Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
title_full_unstemmed Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
title_short Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
title_sort host restriction of lentiviruses and viral countermeasures: apobec3 and vif
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761234/
https://www.ncbi.nlm.nih.gov/pubmed/23903287
http://dx.doi.org/10.3390/v5081934
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