Viral Subversion of the Nuclear Pore Complex

The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficki...

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Detalles Bibliográficos
Autores principales: Le Sage, Valerie, Mouland, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761240/
https://www.ncbi.nlm.nih.gov/pubmed/23959328
http://dx.doi.org/10.3390/v5082019
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author Le Sage, Valerie
Mouland, Andrew J.
author_facet Le Sage, Valerie
Mouland, Andrew J.
author_sort Le Sage, Valerie
collection PubMed
description The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.
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spelling pubmed-37612402013-09-04 Viral Subversion of the Nuclear Pore Complex Le Sage, Valerie Mouland, Andrew J. Viruses Review The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses. MDPI 2013-08-15 /pmc/articles/PMC3761240/ /pubmed/23959328 http://dx.doi.org/10.3390/v5082019 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Le Sage, Valerie
Mouland, Andrew J.
Viral Subversion of the Nuclear Pore Complex
title Viral Subversion of the Nuclear Pore Complex
title_full Viral Subversion of the Nuclear Pore Complex
title_fullStr Viral Subversion of the Nuclear Pore Complex
title_full_unstemmed Viral Subversion of the Nuclear Pore Complex
title_short Viral Subversion of the Nuclear Pore Complex
title_sort viral subversion of the nuclear pore complex
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761240/
https://www.ncbi.nlm.nih.gov/pubmed/23959328
http://dx.doi.org/10.3390/v5082019
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