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Mesenchymal Stem Cells in Tissue Repair
The advent of mesenchymal stem cell (MSC)-based therapies for clinical therapeutics has been an exciting and new innovation for the treatment of a variety of diseases associated with inflammation, tissue damage, and subsequent regeneration and repair. Application-based ability to measure MSC potency...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761350/ https://www.ncbi.nlm.nih.gov/pubmed/24027567 http://dx.doi.org/10.3389/fimmu.2013.00201 |
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author | DiMarino, Amy M. Caplan, Arnold I. Bonfield, Tracey L. |
author_facet | DiMarino, Amy M. Caplan, Arnold I. Bonfield, Tracey L. |
author_sort | DiMarino, Amy M. |
collection | PubMed |
description | The advent of mesenchymal stem cell (MSC)-based therapies for clinical therapeutics has been an exciting and new innovation for the treatment of a variety of diseases associated with inflammation, tissue damage, and subsequent regeneration and repair. Application-based ability to measure MSC potency and fate of the cells post-MSC therapy are the variables that confound the use of MSCs therapeutics in human diseases. An evaluation of MSC function and applications with attention to detail in the preparation as well as quality control and quality assurance are only as good as the assays that are developed. In vivo measures of efficacy and potency require an appreciation of the overall pathophysiology of the model and standardization of outcome measures. The new concepts of how MSC’s participate in the tissue regeneration and wound repair process and further, how this is impacted by estimates of efficacy and potency are important new topics. In this regard, this chapter will review some of the in vitro and in vivo assays for MSC function and activity and their application to the clinical arena. |
format | Online Article Text |
id | pubmed-3761350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37613502013-09-11 Mesenchymal Stem Cells in Tissue Repair DiMarino, Amy M. Caplan, Arnold I. Bonfield, Tracey L. Front Immunol Immunology The advent of mesenchymal stem cell (MSC)-based therapies for clinical therapeutics has been an exciting and new innovation for the treatment of a variety of diseases associated with inflammation, tissue damage, and subsequent regeneration and repair. Application-based ability to measure MSC potency and fate of the cells post-MSC therapy are the variables that confound the use of MSCs therapeutics in human diseases. An evaluation of MSC function and applications with attention to detail in the preparation as well as quality control and quality assurance are only as good as the assays that are developed. In vivo measures of efficacy and potency require an appreciation of the overall pathophysiology of the model and standardization of outcome measures. The new concepts of how MSC’s participate in the tissue regeneration and wound repair process and further, how this is impacted by estimates of efficacy and potency are important new topics. In this regard, this chapter will review some of the in vitro and in vivo assays for MSC function and activity and their application to the clinical arena. Frontiers Media S.A. 2013-09-04 /pmc/articles/PMC3761350/ /pubmed/24027567 http://dx.doi.org/10.3389/fimmu.2013.00201 Text en Copyright © 2013 DiMarino, Caplan and Bonfield. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology DiMarino, Amy M. Caplan, Arnold I. Bonfield, Tracey L. Mesenchymal Stem Cells in Tissue Repair |
title | Mesenchymal Stem Cells in Tissue Repair |
title_full | Mesenchymal Stem Cells in Tissue Repair |
title_fullStr | Mesenchymal Stem Cells in Tissue Repair |
title_full_unstemmed | Mesenchymal Stem Cells in Tissue Repair |
title_short | Mesenchymal Stem Cells in Tissue Repair |
title_sort | mesenchymal stem cells in tissue repair |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761350/ https://www.ncbi.nlm.nih.gov/pubmed/24027567 http://dx.doi.org/10.3389/fimmu.2013.00201 |
work_keys_str_mv | AT dimarinoamym mesenchymalstemcellsintissuerepair AT caplanarnoldi mesenchymalstemcellsintissuerepair AT bonfieldtraceyl mesenchymalstemcellsintissuerepair |