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Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial

Acupuncture is an alternative therapy to induce ovulation in women with polycystic ovary syndrome (PCOS), but there is no study reporting the live birth rate following ovulation induction by acupuncture or its potential as an adjuvant treatment to clomiphene citrate (CC). We assess the efficacy of a...

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Autores principales: Kuang, Hongying, Li, Yan, Wu, Xiaoke, Hou, Lihui, Wu, Taixiang, Liu, Jianping, Ng, Ernest Hung Yu, Stener-Victorin, Elisabet, Legro, Richard S., Zhang, Heping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762180/
https://www.ncbi.nlm.nih.gov/pubmed/24023577
http://dx.doi.org/10.1155/2013/527303
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author Kuang, Hongying
Li, Yan
Wu, Xiaoke
Hou, Lihui
Wu, Taixiang
Liu, Jianping
Ng, Ernest Hung Yu
Stener-Victorin, Elisabet
Legro, Richard S.
Zhang, Heping
author_facet Kuang, Hongying
Li, Yan
Wu, Xiaoke
Hou, Lihui
Wu, Taixiang
Liu, Jianping
Ng, Ernest Hung Yu
Stener-Victorin, Elisabet
Legro, Richard S.
Zhang, Heping
author_sort Kuang, Hongying
collection PubMed
description Acupuncture is an alternative therapy to induce ovulation in women with polycystic ovary syndrome (PCOS), but there is no study reporting the live birth rate following ovulation induction by acupuncture or its potential as an adjuvant treatment to clomiphene citrate (CC). We assess the efficacy of acupuncture with or without CC in achieving live births among 1000 PCOS women in Mainland China. This paper reports the methodology of an ongoing multicenter randomized controlled trial. The randomization scheme is coordinated through the central mechanism and stratified by the participating sites. Participants will be randomized into one of the four treatment arms: (A) true acupuncture and CC, (B) control acupuncture and CC, (C) true acupuncture and placebo CC, and (D) control acupuncture and placebo CC. To ensure the quality and integrity of the trial we have developed a unique multinational team of investigators and Data and Safety Monitoring Board. Up to the end of April 2013, 326 subjects were recruited. In conclusion, the success of this trial will allow us to evaluate the additional benefit of acupuncture beyond the first line medicine for fertility treatment in PCOS women in an unbiased manner.
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spelling pubmed-37621802013-09-10 Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial Kuang, Hongying Li, Yan Wu, Xiaoke Hou, Lihui Wu, Taixiang Liu, Jianping Ng, Ernest Hung Yu Stener-Victorin, Elisabet Legro, Richard S. Zhang, Heping Evid Based Complement Alternat Med Research Article Acupuncture is an alternative therapy to induce ovulation in women with polycystic ovary syndrome (PCOS), but there is no study reporting the live birth rate following ovulation induction by acupuncture or its potential as an adjuvant treatment to clomiphene citrate (CC). We assess the efficacy of acupuncture with or without CC in achieving live births among 1000 PCOS women in Mainland China. This paper reports the methodology of an ongoing multicenter randomized controlled trial. The randomization scheme is coordinated through the central mechanism and stratified by the participating sites. Participants will be randomized into one of the four treatment arms: (A) true acupuncture and CC, (B) control acupuncture and CC, (C) true acupuncture and placebo CC, and (D) control acupuncture and placebo CC. To ensure the quality and integrity of the trial we have developed a unique multinational team of investigators and Data and Safety Monitoring Board. Up to the end of April 2013, 326 subjects were recruited. In conclusion, the success of this trial will allow us to evaluate the additional benefit of acupuncture beyond the first line medicine for fertility treatment in PCOS women in an unbiased manner. Hindawi Publishing Corporation 2013 2013-08-20 /pmc/articles/PMC3762180/ /pubmed/24023577 http://dx.doi.org/10.1155/2013/527303 Text en Copyright © 2013 Hongying Kuang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kuang, Hongying
Li, Yan
Wu, Xiaoke
Hou, Lihui
Wu, Taixiang
Liu, Jianping
Ng, Ernest Hung Yu
Stener-Victorin, Elisabet
Legro, Richard S.
Zhang, Heping
Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial
title Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial
title_full Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial
title_fullStr Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial
title_full_unstemmed Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial
title_short Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial
title_sort acupuncture and clomiphene citrate for live birth in polycystic ovary syndrome: study design of a randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762180/
https://www.ncbi.nlm.nih.gov/pubmed/24023577
http://dx.doi.org/10.1155/2013/527303
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