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Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP

Nucleation promoting factors (NPFs) initiate branched actin network assembly by activating Arp2/3 complex, a branched actin filament nucleator. Cellular actin networks contain multiple NPFs, but how they coordinately regulate Arp2/3 complex is unclear. Cortactin is an NPF that activates Arp2/3 compl...

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Detalles Bibliográficos
Autores principales:	Helgeson, Luke A, Nolen, Brad J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2013
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762189/ https://www.ncbi.nlm.nih.gov/pubmed/24015358 http://dx.doi.org/10.7554/eLife.00884

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