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Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

Cytoplasmic dynein is the predominant minus-end-directed microtubule (MT) motor in most eukaryotic cells. In addition to transporting vesicular cargos, dynein helps to organize MTs within MT networks such as mitotic spindles. How dynein performs such non-canonical functions is unknown. Here we demon...

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Detalles Bibliográficos
Autores principales:	Tanenbaum, Marvin E, Vale, Ronald D, McKenney, Richard J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2013
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762337/ https://www.ncbi.nlm.nih.gov/pubmed/24015359 http://dx.doi.org/10.7554/eLife.00943

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