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Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters

BACKGROUND: QT dispersion (QTd), which is a measure of inhomogeneity of myocardial repolarization, increases following impaired myocardial perfusion. Its prolongation may provide a suitable substrate for life-threatening ventricular arrhythmias. We investigated the changes in QTd and heart rate vari...

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Autores principales: Erdogan, Ercan, Akkaya, Mehmet, Bacaksız, Ahmet, Tasal, Abdurrahman, Sönmez, Osman, Asoglu, Emin, Kul, Seref, Sahın, Musa, Turfan, Murat, Vatankulu, Mehmet Akif, Göktekin, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762394/
https://www.ncbi.nlm.nih.gov/pubmed/23969577
http://dx.doi.org/10.12659/MSM.889511
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author Erdogan, Ercan
Akkaya, Mehmet
Bacaksız, Ahmet
Tasal, Abdurrahman
Sönmez, Osman
Asoglu, Emin
Kul, Seref
Sahın, Musa
Turfan, Murat
Vatankulu, Mehmet Akif
Göktekin, Omer
author_facet Erdogan, Ercan
Akkaya, Mehmet
Bacaksız, Ahmet
Tasal, Abdurrahman
Sönmez, Osman
Asoglu, Emin
Kul, Seref
Sahın, Musa
Turfan, Murat
Vatankulu, Mehmet Akif
Göktekin, Omer
author_sort Erdogan, Ercan
collection PubMed
description BACKGROUND: QT dispersion (QTd), which is a measure of inhomogeneity of myocardial repolarization, increases following impaired myocardial perfusion. Its prolongation may provide a suitable substrate for life-threatening ventricular arrhythmias. We investigated the changes in QTd and heart rate variability (HRV) parameters after successful coronary artery revascularization in a patient with chronic total occlusions (CTO). MATERIAL/METHODS: This study included 139 successfully revascularized CTO patients (118 men, 21 women, mean age 58.3±9.6 years). QTd was measured from a 12-lead electrocardiogram and was defined as the difference between maximum and minimum QT interval. HRV analyses of all subjects were obtained. Frequency domain (LF: HF) and time domain (SDNN, pNN50, and rMSSD) parameters were analyzed. QT intervals were also corrected for heart rate using Bazett’s formula, and the corrected QT interval dispersion (QTcd) was then calculated. All measurements were made before and after percutaneous coronary intervention (PCI). RESULTS: Both QTd and QTcd showed significant improvement following successful revascularization of CTO (55.83±14.79 to 38.87±11.69; p<0.001 and 61.02±16.28 to 42.92±13.41; p<0.001). The revascularization of LAD (n=38), Cx (n=28) and RCA (n=73) resulted in decrease in HRV indices, including SDDN, rMSSD, and pNN50, but none of the variables reached statistical significance. CONCLUSIONS: Successful revascularization of CTO may result in improvement in regional heterogeneity of myocardial repolarization, evidenced as decreased QTcd after the PCI. The revascularization in CTO lesions does not seem to have a significant impact on HRV.
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spelling pubmed-37623942013-09-04 Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters Erdogan, Ercan Akkaya, Mehmet Bacaksız, Ahmet Tasal, Abdurrahman Sönmez, Osman Asoglu, Emin Kul, Seref Sahın, Musa Turfan, Murat Vatankulu, Mehmet Akif Göktekin, Omer Med Sci Monit Clinical Research BACKGROUND: QT dispersion (QTd), which is a measure of inhomogeneity of myocardial repolarization, increases following impaired myocardial perfusion. Its prolongation may provide a suitable substrate for life-threatening ventricular arrhythmias. We investigated the changes in QTd and heart rate variability (HRV) parameters after successful coronary artery revascularization in a patient with chronic total occlusions (CTO). MATERIAL/METHODS: This study included 139 successfully revascularized CTO patients (118 men, 21 women, mean age 58.3±9.6 years). QTd was measured from a 12-lead electrocardiogram and was defined as the difference between maximum and minimum QT interval. HRV analyses of all subjects were obtained. Frequency domain (LF: HF) and time domain (SDNN, pNN50, and rMSSD) parameters were analyzed. QT intervals were also corrected for heart rate using Bazett’s formula, and the corrected QT interval dispersion (QTcd) was then calculated. All measurements were made before and after percutaneous coronary intervention (PCI). RESULTS: Both QTd and QTcd showed significant improvement following successful revascularization of CTO (55.83±14.79 to 38.87±11.69; p<0.001 and 61.02±16.28 to 42.92±13.41; p<0.001). The revascularization of LAD (n=38), Cx (n=28) and RCA (n=73) resulted in decrease in HRV indices, including SDDN, rMSSD, and pNN50, but none of the variables reached statistical significance. CONCLUSIONS: Successful revascularization of CTO may result in improvement in regional heterogeneity of myocardial repolarization, evidenced as decreased QTcd after the PCI. The revascularization in CTO lesions does not seem to have a significant impact on HRV. International Scientific Literature, Inc. 2013-08-23 /pmc/articles/PMC3762394/ /pubmed/23969577 http://dx.doi.org/10.12659/MSM.889511 Text en © Med Sci Monit, 2013 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Erdogan, Ercan
Akkaya, Mehmet
Bacaksız, Ahmet
Tasal, Abdurrahman
Sönmez, Osman
Asoglu, Emin
Kul, Seref
Sahın, Musa
Turfan, Murat
Vatankulu, Mehmet Akif
Göktekin, Omer
Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters
title Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters
title_full Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters
title_fullStr Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters
title_full_unstemmed Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters
title_short Short-term effect of percutaneous recanalization of chronic total occlusions on QT dispersion and heart rate variability parameters
title_sort short-term effect of percutaneous recanalization of chronic total occlusions on qt dispersion and heart rate variability parameters
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762394/
https://www.ncbi.nlm.nih.gov/pubmed/23969577
http://dx.doi.org/10.12659/MSM.889511
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