Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy

BACKGROUND: “Graves’ ophthalmopathy” (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. AIM: The study reported here aimed to...

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Autores principales: Soiberman, Uri, Levy, Ran, Leibovitch, Igal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762670/
https://www.ncbi.nlm.nih.gov/pubmed/24009411
http://dx.doi.org/10.2147/OPTH.S49350
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author Soiberman, Uri
Levy, Ran
Leibovitch, Igal
author_facet Soiberman, Uri
Levy, Ran
Leibovitch, Igal
author_sort Soiberman, Uri
collection PubMed
description BACKGROUND: “Graves’ ophthalmopathy” (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. AIM: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. METHODS: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. RESULTS: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). CONCLUSION: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.
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spelling pubmed-37626702013-09-05 Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy Soiberman, Uri Levy, Ran Leibovitch, Igal Clin Ophthalmol Original Research BACKGROUND: “Graves’ ophthalmopathy” (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. AIM: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. METHODS: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. RESULTS: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). CONCLUSION: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups. Dove Medical Press 2013 2013-08-26 /pmc/articles/PMC3762670/ /pubmed/24009411 http://dx.doi.org/10.2147/OPTH.S49350 Text en © 2013 Soiberman et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.
spellingShingle Original Research
Soiberman, Uri
Levy, Ran
Leibovitch, Igal
Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy
title Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy
title_full Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy
title_fullStr Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy
title_full_unstemmed Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy
title_short Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy
title_sort adiponectin concentration in the orbital fat of patients with graves’ ophthalmopathy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762670/
https://www.ncbi.nlm.nih.gov/pubmed/24009411
http://dx.doi.org/10.2147/OPTH.S49350
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