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Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis

Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the d...

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Autores principales: Li, Xin, Xu, Fan, Xie, Liang, Ji, Yongjia, Cheng, Ke, Zhou, Qinmin, Wang, Tao, Shively, Carol, Wu, Qingyuan, Gong, Wei, Fang, Liang, Zhan, Qunlin, Melgiri, N. D., Xie, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762720/
https://www.ncbi.nlm.nih.gov/pubmed/24023857
http://dx.doi.org/10.1371/journal.pone.0073293
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author Li, Xin
Xu, Fan
Xie, Liang
Ji, Yongjia
Cheng, Ke
Zhou, Qinmin
Wang, Tao
Shively, Carol
Wu, Qingyuan
Gong, Wei
Fang, Liang
Zhan, Qunlin
Melgiri, N. D.
Xie, Peng
author_facet Li, Xin
Xu, Fan
Xie, Liang
Ji, Yongjia
Cheng, Ke
Zhou, Qinmin
Wang, Tao
Shively, Carol
Wu, Qingyuan
Gong, Wei
Fang, Liang
Zhan, Qunlin
Melgiri, N. D.
Xie, Peng
author_sort Li, Xin
collection PubMed
description Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limited homologies with humans. Therefore, a more homologous primate model of depression is needed to advance investigation into the pathophysiological mechanisms underlying depression and to conduct pre-clinical therapeutic trials. Here, we report two convenient methods – social isolation and social plus visual isolation – which can be applied to construct a non-human primate model of depression in the adult female cynomolgus monkey (Macaca fascicularis). Both social and social plus visual isolation were shown to be effective in inducing depression-like behavior by significantly reducing socially dominant aggressive conflict behavior, communicative behavior, sexual behavior, and parental behavior. The addition of visual isolation produced more profound behavioral changes than social isolation alone by further reducing parental behavior and sexual behavior. Thus, the degree of behavioral pathology may be manipulated by the degree of isolation. These methods can be applied to construct a non-human primate model of depression in order to assess physiological, behavioral, and social phenomena in a controlled laboratory setting.
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spelling pubmed-37627202013-09-10 Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis Li, Xin Xu, Fan Xie, Liang Ji, Yongjia Cheng, Ke Zhou, Qinmin Wang, Tao Shively, Carol Wu, Qingyuan Gong, Wei Fang, Liang Zhan, Qunlin Melgiri, N. D. Xie, Peng PLoS One Research Article Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limited homologies with humans. Therefore, a more homologous primate model of depression is needed to advance investigation into the pathophysiological mechanisms underlying depression and to conduct pre-clinical therapeutic trials. Here, we report two convenient methods – social isolation and social plus visual isolation – which can be applied to construct a non-human primate model of depression in the adult female cynomolgus monkey (Macaca fascicularis). Both social and social plus visual isolation were shown to be effective in inducing depression-like behavior by significantly reducing socially dominant aggressive conflict behavior, communicative behavior, sexual behavior, and parental behavior. The addition of visual isolation produced more profound behavioral changes than social isolation alone by further reducing parental behavior and sexual behavior. Thus, the degree of behavioral pathology may be manipulated by the degree of isolation. These methods can be applied to construct a non-human primate model of depression in order to assess physiological, behavioral, and social phenomena in a controlled laboratory setting. Public Library of Science 2013-09-04 /pmc/articles/PMC3762720/ /pubmed/24023857 http://dx.doi.org/10.1371/journal.pone.0073293 Text en © 2013 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Xin
Xu, Fan
Xie, Liang
Ji, Yongjia
Cheng, Ke
Zhou, Qinmin
Wang, Tao
Shively, Carol
Wu, Qingyuan
Gong, Wei
Fang, Liang
Zhan, Qunlin
Melgiri, N. D.
Xie, Peng
Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
title Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
title_full Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
title_fullStr Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
title_full_unstemmed Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
title_short Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
title_sort depression-like behavioral phenotypes by social and social plus visual isolation in the adult female macaca fascicularis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762720/
https://www.ncbi.nlm.nih.gov/pubmed/24023857
http://dx.doi.org/10.1371/journal.pone.0073293
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