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Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the d...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762720/ https://www.ncbi.nlm.nih.gov/pubmed/24023857 http://dx.doi.org/10.1371/journal.pone.0073293 |
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author | Li, Xin Xu, Fan Xie, Liang Ji, Yongjia Cheng, Ke Zhou, Qinmin Wang, Tao Shively, Carol Wu, Qingyuan Gong, Wei Fang, Liang Zhan, Qunlin Melgiri, N. D. Xie, Peng |
author_facet | Li, Xin Xu, Fan Xie, Liang Ji, Yongjia Cheng, Ke Zhou, Qinmin Wang, Tao Shively, Carol Wu, Qingyuan Gong, Wei Fang, Liang Zhan, Qunlin Melgiri, N. D. Xie, Peng |
author_sort | Li, Xin |
collection | PubMed |
description | Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limited homologies with humans. Therefore, a more homologous primate model of depression is needed to advance investigation into the pathophysiological mechanisms underlying depression and to conduct pre-clinical therapeutic trials. Here, we report two convenient methods – social isolation and social plus visual isolation – which can be applied to construct a non-human primate model of depression in the adult female cynomolgus monkey (Macaca fascicularis). Both social and social plus visual isolation were shown to be effective in inducing depression-like behavior by significantly reducing socially dominant aggressive conflict behavior, communicative behavior, sexual behavior, and parental behavior. The addition of visual isolation produced more profound behavioral changes than social isolation alone by further reducing parental behavior and sexual behavior. Thus, the degree of behavioral pathology may be manipulated by the degree of isolation. These methods can be applied to construct a non-human primate model of depression in order to assess physiological, behavioral, and social phenomena in a controlled laboratory setting. |
format | Online Article Text |
id | pubmed-3762720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37627202013-09-10 Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis Li, Xin Xu, Fan Xie, Liang Ji, Yongjia Cheng, Ke Zhou, Qinmin Wang, Tao Shively, Carol Wu, Qingyuan Gong, Wei Fang, Liang Zhan, Qunlin Melgiri, N. D. Xie, Peng PLoS One Research Article Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limited homologies with humans. Therefore, a more homologous primate model of depression is needed to advance investigation into the pathophysiological mechanisms underlying depression and to conduct pre-clinical therapeutic trials. Here, we report two convenient methods – social isolation and social plus visual isolation – which can be applied to construct a non-human primate model of depression in the adult female cynomolgus monkey (Macaca fascicularis). Both social and social plus visual isolation were shown to be effective in inducing depression-like behavior by significantly reducing socially dominant aggressive conflict behavior, communicative behavior, sexual behavior, and parental behavior. The addition of visual isolation produced more profound behavioral changes than social isolation alone by further reducing parental behavior and sexual behavior. Thus, the degree of behavioral pathology may be manipulated by the degree of isolation. These methods can be applied to construct a non-human primate model of depression in order to assess physiological, behavioral, and social phenomena in a controlled laboratory setting. Public Library of Science 2013-09-04 /pmc/articles/PMC3762720/ /pubmed/24023857 http://dx.doi.org/10.1371/journal.pone.0073293 Text en © 2013 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Li, Xin Xu, Fan Xie, Liang Ji, Yongjia Cheng, Ke Zhou, Qinmin Wang, Tao Shively, Carol Wu, Qingyuan Gong, Wei Fang, Liang Zhan, Qunlin Melgiri, N. D. Xie, Peng Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis |
title | Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
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title_full | Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
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title_fullStr | Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
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title_full_unstemmed | Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
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title_short | Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis
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title_sort | depression-like behavioral phenotypes by social and social plus visual isolation in the adult female macaca fascicularis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762720/ https://www.ncbi.nlm.nih.gov/pubmed/24023857 http://dx.doi.org/10.1371/journal.pone.0073293 |
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