Cargando…

Lrig2-Deficient Mice Are Protected against PDGFB-Induced Glioma

BACKGROUND: The leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins constitute an integral membrane protein family that has three members: LRIG1, LRIG2, and LRIG3. LRIG1 negatively regulates growth factor signaling, but little is known regarding the functions of LRIG2 and LRIG3. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rondahl, Veronica, Holmlund, Camilla, Karlsson, Terese, Wang, Baofeng, Faraz, Mahmood, Henriksson, Roger, Hedman, Håkan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762791/ https://www.ncbi.nlm.nih.gov/pubmed/24023893 http://dx.doi.org/10.1371/journal.pone.0073635

Ejemplares similares

Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma
por: Mao, Feng, et al.
Publicado: (2018)

A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors
por: Faraz, Mahmood, et al.
Publicado: (2018)

LRIG and cancer prognosis
por: Lindquist, David, et al.
Publicado: (2014)

LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer
por: Faraz, Mahmood, et al.
Publicado: (2020)

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
por: Herdenberg, Carl, et al.
Publicado: (2021)

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma
por: Thomasson, Marcus, et al.
Publicado: (2012)

Co-incidental increase in gene copy number of ERBB2 and LRIG1 in breast cancer
por: Ljuslinder, Ingrid, et al.
Publicado: (2009)

LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer
por: Lindquist, David, et al.
Publicado: (2018)

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status
por: Johansson, Mikael, et al.
Publicado: (2013)

HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling?
por: Herdenberg, Carl, et al.
Publicado: (2022)

The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma
por: Cheng, Fangling, et al.
Publicado: (2019)

Expression of LRIG1 is associated with good prognosis and human papillomavirus status in oropharyngeal cancer
por: Lindquist, D, et al.
Publicado: (2014)

Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
por: Ranhem, Cecilia, et al.
Publicado: (2017)

Corrigendum: The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma
por: Cheng, Fangling, et al.
Publicado: (2020)

LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–PCR and immunohistochemical analysis
por: Thomasson, M, et al.
Publicado: (2003)

LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–RCR and immunohistochemical analysis
por: Thomasson, M, et al.
Publicado: (2004)

Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder
por: Roberts, Neil A., et al.
Publicado: (2019)

LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance
por: Billing, Ola, et al.
Publicado: (2021)

LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma
por: Peng, Chenghao, et al.
Publicado: (2021)

Multiparametric Longitudinal Profiling of RCAS-tva-Induced PDGFB-Driven Experimental Glioma
por: Becker, Hannes, et al.
Publicado: (2022)

Glioma-derived LRIG3 interacts with NETO2 in tumor-associated macrophages to modulate microenvironment and suppress tumor growth
por: Li, Youwei, et al.
Publicado: (2023)

Soluble LRIG2 Ectodomain Is Released from Glioblastoma Cells and Promotes the Proliferation and Inhibits the Apoptosis of Glioblastoma Cells In Vitro and In Vivo in a Similar Manner to the Full-Length LRIG2
por: Xiao, Qungen, et al.
Publicado: (2014)

Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas
por: Weishaupt, Holger, et al.
Publicado: (2022)

Corrigendum to: Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas
Publicado: (2023)

LRIG1-2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV-DNA and p16(INK4a) status
por: Stefansson, Kristina, et al.
Publicado: (2019)

Downregulation of LRIG2 expression inhibits angiogenesis of glioma via EGFR/VEGF-A pathway
por: Yang, Hong-Kuan, et al.
Publicado: (2017)

Progressive brain calcifications and signs in a family with the L9R mutation in the PDGFB gene
por: Paucar, Martin, et al.
Publicado: (2016)

Familial Brain Calcifications With Leukoencephalopathy: A Novel PDGFB Variant
por: Shen, Jack, et al.
Publicado: (2022)

LRIG1 expression and colorectal cancer prognosis
por: Bakherad, Maryam, et al.
Publicado: (2021)

The Prognostic Role of LRIG Proteins in Endometrial Cancer
por: Razumova, Zoia, et al.
Publicado: (2021)

LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells
por: Guo, Zhentao, et al.
Publicado: (2014)

miR-503 Inhibits Proliferation, Migration, And Angiogenesis Of Glioma By Acting On VEGFA Through Targeting LRIG2
por: Sun, Sheng-Li, et al.
Publicado: (2019)

White matter involvement in a family with a novel PDGFB mutation
por: Biancheri, Roberta, et al.
Publicado: (2016)

A systems genetics approach to revealing the Pdgfb molecular network of the retina
por: Li, Shasha, et al.
Publicado: (2020)

Living with primary brain calcification with PDGFB variants: A qualitative study
por: Takeuchi, Tomiko, et al.
Publicado: (2022)

Lrig1 Expression in Human Sebaceous Gland Tumors
por: Pünchera, Jöri, et al.
Publicado: (2016)

Vertebrate Lrig3-ErbB Interactions Occur In Vitro but Are Unlikely to Play a Role in Lrig3-Dependent Inner Ear Morphogenesis
por: Abraira, Victoria E., et al.
Publicado: (2010)

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification
por: Vanlandewijck, Michael, et al.
Publicado: (2015)

Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
por: Kyi, Priscilla, et al.
Publicado: (2022)

A SOX17-PDGFB signaling axis regulates aortic root development
por: Lu, Pengfei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tbfrsi3pmm55s5i92s4sf410go