Cargando…

Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus

OBJECTIVE: This review aimed to comprehensively assess the literature examining a possible link between the rs1801133 polymorphism (677C→T) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) gene and risk of type 2 diabetes mellitus (DM). RESEARCH DESIGN AND METHODS: Several resear...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhong, Jian-Hong, Rodríguez, A. Chapin, Yang, Na-Na, Li, Le-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762795/
https://www.ncbi.nlm.nih.gov/pubmed/24023947
http://dx.doi.org/10.1371/journal.pone.0074521
_version_ 1782282934864052224
author Zhong, Jian-Hong
Rodríguez, A. Chapin
Yang, Na-Na
Li, Le-Qun
author_facet Zhong, Jian-Hong
Rodríguez, A. Chapin
Yang, Na-Na
Li, Le-Qun
author_sort Zhong, Jian-Hong
collection PubMed
description OBJECTIVE: This review aimed to comprehensively assess the literature examining a possible link between the rs1801133 polymorphism (677C→T) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) gene and risk of type 2 diabetes mellitus (DM). RESEARCH DESIGN AND METHODS: Several research databases were systematically searched for studies examining the genotype at the rs1801133 polymorphism in healthy control individuals and individuals with type 2 DM. Genotype frequency data were examined across all studies and across subsets of studies according to ethnicity and presence of serious DM-related complications. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: A total of 4855 individuals with type 2 DM and 5242 healthy controls from 15 countries comprising Asian, Caucasian and African ethnicities were found to satisfy the inclusion criteria and included in the review. Genotype at the rs1801133 polymorphism was not consistently associated with either increased or reduced risk of type 2 DM; the OR across all studies was 0.91 (95%CI 0.82 to 1.00) for the C- vs. T-allele, 0.88 (0.75 to 1.03) for CC vs. CT+TT, 0.82 (0.71 to 0.95) for CC vs. TT, and 1.15 (1.03 to 1.29) for TT vs. CC+CT. Similar results were found when the meta-analysis was repeated separately for each ethnic subgroup, and for subgroups with or without serious DM-related complications. CONCLUSIONS: There does not appear to be compelling evidence of an association between the genotype at the rs1801133 polymorphism of the MTHFR gene and risk of type 2 DM.
format Online
Article
Text
id pubmed-3762795
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-37627952013-09-10 Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus Zhong, Jian-Hong Rodríguez, A. Chapin Yang, Na-Na Li, Le-Qun PLoS One Research Article OBJECTIVE: This review aimed to comprehensively assess the literature examining a possible link between the rs1801133 polymorphism (677C→T) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) gene and risk of type 2 diabetes mellitus (DM). RESEARCH DESIGN AND METHODS: Several research databases were systematically searched for studies examining the genotype at the rs1801133 polymorphism in healthy control individuals and individuals with type 2 DM. Genotype frequency data were examined across all studies and across subsets of studies according to ethnicity and presence of serious DM-related complications. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: A total of 4855 individuals with type 2 DM and 5242 healthy controls from 15 countries comprising Asian, Caucasian and African ethnicities were found to satisfy the inclusion criteria and included in the review. Genotype at the rs1801133 polymorphism was not consistently associated with either increased or reduced risk of type 2 DM; the OR across all studies was 0.91 (95%CI 0.82 to 1.00) for the C- vs. T-allele, 0.88 (0.75 to 1.03) for CC vs. CT+TT, 0.82 (0.71 to 0.95) for CC vs. TT, and 1.15 (1.03 to 1.29) for TT vs. CC+CT. Similar results were found when the meta-analysis was repeated separately for each ethnic subgroup, and for subgroups with or without serious DM-related complications. CONCLUSIONS: There does not appear to be compelling evidence of an association between the genotype at the rs1801133 polymorphism of the MTHFR gene and risk of type 2 DM. Public Library of Science 2013-09-04 /pmc/articles/PMC3762795/ /pubmed/24023947 http://dx.doi.org/10.1371/journal.pone.0074521 Text en © 2013 Zhong et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhong, Jian-Hong
Rodríguez, A. Chapin
Yang, Na-Na
Li, Le-Qun
Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus
title Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus
title_full Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus
title_fullStr Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus
title_full_unstemmed Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus
title_short Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus
title_sort methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762795/
https://www.ncbi.nlm.nih.gov/pubmed/24023947
http://dx.doi.org/10.1371/journal.pone.0074521
work_keys_str_mv AT zhongjianhong methylenetetrahydrofolatereductasegenepolymorphismandriskoftype2diabetesmellitus
AT rodriguezachapin methylenetetrahydrofolatereductasegenepolymorphismandriskoftype2diabetesmellitus
AT yangnana methylenetetrahydrofolatereductasegenepolymorphismandriskoftype2diabetesmellitus
AT lilequn methylenetetrahydrofolatereductasegenepolymorphismandriskoftype2diabetesmellitus