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Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients
Clinical data indicate that prognostic stratification of radically resected colorectal cancer based on disease stage only may not be always be adequate. Preclinical findings suggest that cancer stem cells may influence the biological behaviour of colorectal cancer independently from stage: objective...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762853/ https://www.ncbi.nlm.nih.gov/pubmed/24023782 http://dx.doi.org/10.1371/journal.pone.0072843 |
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author | Giampieri, Riccardo Scartozzi, Mario Loretelli, Cristian Piva, Francesco Mandolesi, Alessandra Lezoche, Giovanni Prete, Michela Del Bittoni, Alessandro Faloppi, Luca Bianconi, Maristella Cecchini, Luca Guerrieri, Mario Bearzi, Italo Cascinu, Stefano |
author_facet | Giampieri, Riccardo Scartozzi, Mario Loretelli, Cristian Piva, Francesco Mandolesi, Alessandra Lezoche, Giovanni Prete, Michela Del Bittoni, Alessandro Faloppi, Luca Bianconi, Maristella Cecchini, Luca Guerrieri, Mario Bearzi, Italo Cascinu, Stefano |
author_sort | Giampieri, Riccardo |
collection | PubMed |
description | Clinical data indicate that prognostic stratification of radically resected colorectal cancer based on disease stage only may not be always be adequate. Preclinical findings suggest that cancer stem cells may influence the biological behaviour of colorectal cancer independently from stage: objective of the study was to assess whether a panel of stemness markers were correlated with clinical outcome in resected stage II and III colon cancer patients. A panel of 66 markers of stemness were analysed and thus patients were divided into two groups (A and B) with most patients clustering in a manner consistent with different time to relapse by using a statistical algorithm. A total of 62 patients were analysed. Thirty-six (58%) relapsed during the follow-up period (range 1.63–86.5 months). Twelve (19%) and 50 (81%) patients were allocated into group A and B, respectively. A significantly different median relapse-free survival was observed between the 2 groups (22.18 vs 42.85 months, p = 0.0296). Among of all genes tested, those with the higher “weight” in determining different prognosis were CD44, ALCAM, DTX2, HSPA9, CCNA2, PDX1, MYST1, COL1A1 and ABCG2. This analysis supports the idea that, other than stage, biological variables, such as expression levels of colon cancer stem cell genes, may be relevant in determining an increased risk of relapse in resected colorectal cancer patients. |
format | Online Article Text |
id | pubmed-3762853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37628532013-09-10 Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients Giampieri, Riccardo Scartozzi, Mario Loretelli, Cristian Piva, Francesco Mandolesi, Alessandra Lezoche, Giovanni Prete, Michela Del Bittoni, Alessandro Faloppi, Luca Bianconi, Maristella Cecchini, Luca Guerrieri, Mario Bearzi, Italo Cascinu, Stefano PLoS One Research Article Clinical data indicate that prognostic stratification of radically resected colorectal cancer based on disease stage only may not be always be adequate. Preclinical findings suggest that cancer stem cells may influence the biological behaviour of colorectal cancer independently from stage: objective of the study was to assess whether a panel of stemness markers were correlated with clinical outcome in resected stage II and III colon cancer patients. A panel of 66 markers of stemness were analysed and thus patients were divided into two groups (A and B) with most patients clustering in a manner consistent with different time to relapse by using a statistical algorithm. A total of 62 patients were analysed. Thirty-six (58%) relapsed during the follow-up period (range 1.63–86.5 months). Twelve (19%) and 50 (81%) patients were allocated into group A and B, respectively. A significantly different median relapse-free survival was observed between the 2 groups (22.18 vs 42.85 months, p = 0.0296). Among of all genes tested, those with the higher “weight” in determining different prognosis were CD44, ALCAM, DTX2, HSPA9, CCNA2, PDX1, MYST1, COL1A1 and ABCG2. This analysis supports the idea that, other than stage, biological variables, such as expression levels of colon cancer stem cell genes, may be relevant in determining an increased risk of relapse in resected colorectal cancer patients. Public Library of Science 2013-09-04 /pmc/articles/PMC3762853/ /pubmed/24023782 http://dx.doi.org/10.1371/journal.pone.0072843 Text en © 2013 Giampieri et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Giampieri, Riccardo Scartozzi, Mario Loretelli, Cristian Piva, Francesco Mandolesi, Alessandra Lezoche, Giovanni Prete, Michela Del Bittoni, Alessandro Faloppi, Luca Bianconi, Maristella Cecchini, Luca Guerrieri, Mario Bearzi, Italo Cascinu, Stefano Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients |
title | Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients |
title_full | Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients |
title_fullStr | Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients |
title_full_unstemmed | Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients |
title_short | Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients |
title_sort | cancer stem cell gene profile as predictor of relapse in high risk stage ii and stage iii, radically resected colon cancer patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762853/ https://www.ncbi.nlm.nih.gov/pubmed/24023782 http://dx.doi.org/10.1371/journal.pone.0072843 |
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