Trash or Treasure: extracellular microRNAs and cell-to-cell communication

Circulating RNAs in human body fluids are promising candidates for diagnostic purposes. However, the biological significance of circulating RNAs remains elusive. Recently, small non-coding RNAs, microRNAs (miRNAs), were isolated from multiple human body fluids, and these “circulating miRNAs” have be...

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Autores principales: Kosaka, Nobuyoshi, Yoshioka, Yusuke, Hagiwara, Keitaro, Tominaga, Naoomi, Katsuda, Takeshi, Ochiya, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763217/
https://www.ncbi.nlm.nih.gov/pubmed/24046777
http://dx.doi.org/10.3389/fgene.2013.00173
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author Kosaka, Nobuyoshi
Yoshioka, Yusuke
Hagiwara, Keitaro
Tominaga, Naoomi
Katsuda, Takeshi
Ochiya, Takahiro
author_facet Kosaka, Nobuyoshi
Yoshioka, Yusuke
Hagiwara, Keitaro
Tominaga, Naoomi
Katsuda, Takeshi
Ochiya, Takahiro
author_sort Kosaka, Nobuyoshi
collection PubMed
description Circulating RNAs in human body fluids are promising candidates for diagnostic purposes. However, the biological significance of circulating RNAs remains elusive. Recently, small non-coding RNAs, microRNAs (miRNAs), were isolated from multiple human body fluids, and these “circulating miRNAs” have been implicated as novel disease biomarkers. Concurrently, miRNAs were also identified in the extracellular space associated with extracellular vesicles (EVs), which are small membrane vesicles secreted from various types of cells. The function of these secreted miRNAs has been revealed in several papers. Circulating miRNAs have been experimentally found to be associated with EVs; however, other types of extracellular miRNAs were also described. This review discusses studies related to extracellular miRNAs, including circulating miRNAs and secreted miRNAs, to highlight the importance of studying not only secreted miRNAs, but also circulating miRNAs to determine the contribution of extracellular miRNAs especially in cancer development.
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spelling pubmed-37632172013-09-17 Trash or Treasure: extracellular microRNAs and cell-to-cell communication Kosaka, Nobuyoshi Yoshioka, Yusuke Hagiwara, Keitaro Tominaga, Naoomi Katsuda, Takeshi Ochiya, Takahiro Front Genet Genetics Circulating RNAs in human body fluids are promising candidates for diagnostic purposes. However, the biological significance of circulating RNAs remains elusive. Recently, small non-coding RNAs, microRNAs (miRNAs), were isolated from multiple human body fluids, and these “circulating miRNAs” have been implicated as novel disease biomarkers. Concurrently, miRNAs were also identified in the extracellular space associated with extracellular vesicles (EVs), which are small membrane vesicles secreted from various types of cells. The function of these secreted miRNAs has been revealed in several papers. Circulating miRNAs have been experimentally found to be associated with EVs; however, other types of extracellular miRNAs were also described. This review discusses studies related to extracellular miRNAs, including circulating miRNAs and secreted miRNAs, to highlight the importance of studying not only secreted miRNAs, but also circulating miRNAs to determine the contribution of extracellular miRNAs especially in cancer development. Frontiers Media S.A. 2013-09-05 /pmc/articles/PMC3763217/ /pubmed/24046777 http://dx.doi.org/10.3389/fgene.2013.00173 Text en Copyright © Kosaka, Yoshioka, Hagiwara, Tominaga, Katsuda and Ochiya. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Kosaka, Nobuyoshi
Yoshioka, Yusuke
Hagiwara, Keitaro
Tominaga, Naoomi
Katsuda, Takeshi
Ochiya, Takahiro
Trash or Treasure: extracellular microRNAs and cell-to-cell communication
title Trash or Treasure: extracellular microRNAs and cell-to-cell communication
title_full Trash or Treasure: extracellular microRNAs and cell-to-cell communication
title_fullStr Trash or Treasure: extracellular microRNAs and cell-to-cell communication
title_full_unstemmed Trash or Treasure: extracellular microRNAs and cell-to-cell communication
title_short Trash or Treasure: extracellular microRNAs and cell-to-cell communication
title_sort trash or treasure: extracellular micrornas and cell-to-cell communication
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763217/
https://www.ncbi.nlm.nih.gov/pubmed/24046777
http://dx.doi.org/10.3389/fgene.2013.00173
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