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Antimelanoma and Antityrosinase from Alpinia galangal Constituents
Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763262/ https://www.ncbi.nlm.nih.gov/pubmed/24027439 http://dx.doi.org/10.1155/2013/186505 |
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author | Lo, Chih-Yu Liu, Po-Len Lin, Li-Ching Chen, Yen-Ting Hseu, You-Cheng Wen, Zhi-Hong Wang, Hui-Min |
author_facet | Lo, Chih-Yu Liu, Po-Len Lin, Li-Ching Chen, Yen-Ting Hseu, You-Cheng Wen, Zhi-Hong Wang, Hui-Min |
author_sort | Lo, Chih-Yu |
collection | PubMed |
description | Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry. |
format | Online Article Text |
id | pubmed-3763262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37632622013-09-11 Antimelanoma and Antityrosinase from Alpinia galangal Constituents Lo, Chih-Yu Liu, Po-Len Lin, Li-Ching Chen, Yen-Ting Hseu, You-Cheng Wen, Zhi-Hong Wang, Hui-Min ScientificWorldJournal Research Article Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry. Hindawi Publishing Corporation 2013-08-21 /pmc/articles/PMC3763262/ /pubmed/24027439 http://dx.doi.org/10.1155/2013/186505 Text en Copyright © 2013 Chih-Yu Lo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lo, Chih-Yu Liu, Po-Len Lin, Li-Ching Chen, Yen-Ting Hseu, You-Cheng Wen, Zhi-Hong Wang, Hui-Min Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
title | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
title_full | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
title_fullStr | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
title_full_unstemmed | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
title_short | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
title_sort | antimelanoma and antityrosinase from alpinia galangal constituents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763262/ https://www.ncbi.nlm.nih.gov/pubmed/24027439 http://dx.doi.org/10.1155/2013/186505 |
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