The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer

Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and ani...

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Detalles Bibliográficos
Autores principales: Wang, Dingzhi, Xia, Dianren, DuBois, Raymond N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763401/
https://www.ncbi.nlm.nih.gov/pubmed/24213116
http://dx.doi.org/10.3390/cancers3043894
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author Wang, Dingzhi
Xia, Dianren
DuBois, Raymond N.
author_facet Wang, Dingzhi
Xia, Dianren
DuBois, Raymond N.
author_sort Wang, Dingzhi
collection PubMed
description Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.
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spelling pubmed-37634012013-09-05 The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer Wang, Dingzhi Xia, Dianren DuBois, Raymond N. Cancers (Basel) Review Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer. Molecular Diversity Preservation International (MDPI) 2011-10-14 /pmc/articles/PMC3763401/ /pubmed/24213116 http://dx.doi.org/10.3390/cancers3043894 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license(http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Wang, Dingzhi
Xia, Dianren
DuBois, Raymond N.
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_full The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_fullStr The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_full_unstemmed The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_short The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_sort crosstalk of ptgs2 and egf signaling pathways in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763401/
https://www.ncbi.nlm.nih.gov/pubmed/24213116
http://dx.doi.org/10.3390/cancers3043894
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