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Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues
Helical Tomotherapy (HT) is a highly conformal image-guided radiation technique, introduced into clinical routine in 2006 at the Centro di Riferimento Oncologico Aviano (Italy). With this new technology, intensity-modulated radiotherapy (IMRT) is delivered using a helicoidal method. Here we present...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763405/ https://www.ncbi.nlm.nih.gov/pubmed/24213120 http://dx.doi.org/10.3390/cancers3043972 |
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author | Mascarin, Maurizio Giugliano, Francesca Maria Coassin, Elisa Drigo, Annalisa Chiovati, Paola Dassie, Andrea Franchin, Giovanni Minatel, Emilio Trovò, Mauro Gaetano |
author_facet | Mascarin, Maurizio Giugliano, Francesca Maria Coassin, Elisa Drigo, Annalisa Chiovati, Paola Dassie, Andrea Franchin, Giovanni Minatel, Emilio Trovò, Mauro Gaetano |
author_sort | Mascarin, Maurizio |
collection | PubMed |
description | Helical Tomotherapy (HT) is a highly conformal image-guided radiation technique, introduced into clinical routine in 2006 at the Centro di Riferimento Oncologico Aviano (Italy). With this new technology, intensity-modulated radiotherapy (IMRT) is delivered using a helicoidal method. Here we present our dosimetric experiences using HT in 100 children, adolescents and young adults treated from May 2006 to February 2011. The median age of the patients was 13 years (range 1–24). The most common treated site was the central nervous system (50; of these, 24 were craniospinal irradiations), followed by thorax (22), head and neck (10), abdomen and pelvis (11), and limbs (7). The use of HT was calculated in accordance to the target dose conformation, the target size and shape, the dose to critical organs adjacent to the target, simultaneous treatment of multiple targets, and re-irradiation. HT has demonstrated to improve target volume dose homogeneity and the sparing of critical structures, when compared to 3D Linac-based radiotherapy (RT). In standard cases this technique represented a comparable alternative to IMRT delivered with conventional linear accelerator. In certain cases (e.g., craniospinal and pleural treatments) only HT generated adequate treatment plans with good target volume coverage. However, the gain in target conformality should be balanced with the spread of low-doses to distant areas. This remains an open issue for the potential risk of secondary malignancies (SMNs) and longer follow-up is mandatory. |
format | Online Article Text |
id | pubmed-3763405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37634052013-09-05 Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues Mascarin, Maurizio Giugliano, Francesca Maria Coassin, Elisa Drigo, Annalisa Chiovati, Paola Dassie, Andrea Franchin, Giovanni Minatel, Emilio Trovò, Mauro Gaetano Cancers (Basel) Article Helical Tomotherapy (HT) is a highly conformal image-guided radiation technique, introduced into clinical routine in 2006 at the Centro di Riferimento Oncologico Aviano (Italy). With this new technology, intensity-modulated radiotherapy (IMRT) is delivered using a helicoidal method. Here we present our dosimetric experiences using HT in 100 children, adolescents and young adults treated from May 2006 to February 2011. The median age of the patients was 13 years (range 1–24). The most common treated site was the central nervous system (50; of these, 24 were craniospinal irradiations), followed by thorax (22), head and neck (10), abdomen and pelvis (11), and limbs (7). The use of HT was calculated in accordance to the target dose conformation, the target size and shape, the dose to critical organs adjacent to the target, simultaneous treatment of multiple targets, and re-irradiation. HT has demonstrated to improve target volume dose homogeneity and the sparing of critical structures, when compared to 3D Linac-based radiotherapy (RT). In standard cases this technique represented a comparable alternative to IMRT delivered with conventional linear accelerator. In certain cases (e.g., craniospinal and pleural treatments) only HT generated adequate treatment plans with good target volume coverage. However, the gain in target conformality should be balanced with the spread of low-doses to distant areas. This remains an open issue for the potential risk of secondary malignancies (SMNs) and longer follow-up is mandatory. Molecular Diversity Preservation International (MDPI) 2011-10-25 /pmc/articles/PMC3763405/ /pubmed/24213120 http://dx.doi.org/10.3390/cancers3043972 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Mascarin, Maurizio Giugliano, Francesca Maria Coassin, Elisa Drigo, Annalisa Chiovati, Paola Dassie, Andrea Franchin, Giovanni Minatel, Emilio Trovò, Mauro Gaetano Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues |
title | Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues |
title_full | Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues |
title_fullStr | Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues |
title_full_unstemmed | Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues |
title_short | Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues |
title_sort | helical tomotherapy in children and adolescents: dosimetric comparisons, opportunities and issues |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763405/ https://www.ncbi.nlm.nih.gov/pubmed/24213120 http://dx.doi.org/10.3390/cancers3043972 |
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