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Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues

Helical Tomotherapy (HT) is a highly conformal image-guided radiation technique, introduced into clinical routine in 2006 at the Centro di Riferimento Oncologico Aviano (Italy). With this new technology, intensity-modulated radiotherapy (IMRT) is delivered using a helicoidal method. Here we present...

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Autores principales: Mascarin, Maurizio, Giugliano, Francesca Maria, Coassin, Elisa, Drigo, Annalisa, Chiovati, Paola, Dassie, Andrea, Franchin, Giovanni, Minatel, Emilio, Trovò, Mauro Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763405/
https://www.ncbi.nlm.nih.gov/pubmed/24213120
http://dx.doi.org/10.3390/cancers3043972
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author Mascarin, Maurizio
Giugliano, Francesca Maria
Coassin, Elisa
Drigo, Annalisa
Chiovati, Paola
Dassie, Andrea
Franchin, Giovanni
Minatel, Emilio
Trovò, Mauro Gaetano
author_facet Mascarin, Maurizio
Giugliano, Francesca Maria
Coassin, Elisa
Drigo, Annalisa
Chiovati, Paola
Dassie, Andrea
Franchin, Giovanni
Minatel, Emilio
Trovò, Mauro Gaetano
author_sort Mascarin, Maurizio
collection PubMed
description Helical Tomotherapy (HT) is a highly conformal image-guided radiation technique, introduced into clinical routine in 2006 at the Centro di Riferimento Oncologico Aviano (Italy). With this new technology, intensity-modulated radiotherapy (IMRT) is delivered using a helicoidal method. Here we present our dosimetric experiences using HT in 100 children, adolescents and young adults treated from May 2006 to February 2011. The median age of the patients was 13 years (range 1–24). The most common treated site was the central nervous system (50; of these, 24 were craniospinal irradiations), followed by thorax (22), head and neck (10), abdomen and pelvis (11), and limbs (7). The use of HT was calculated in accordance to the target dose conformation, the target size and shape, the dose to critical organs adjacent to the target, simultaneous treatment of multiple targets, and re-irradiation. HT has demonstrated to improve target volume dose homogeneity and the sparing of critical structures, when compared to 3D Linac-based radiotherapy (RT). In standard cases this technique represented a comparable alternative to IMRT delivered with conventional linear accelerator. In certain cases (e.g., craniospinal and pleural treatments) only HT generated adequate treatment plans with good target volume coverage. However, the gain in target conformality should be balanced with the spread of low-doses to distant areas. This remains an open issue for the potential risk of secondary malignancies (SMNs) and longer follow-up is mandatory.
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spelling pubmed-37634052013-09-05 Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues Mascarin, Maurizio Giugliano, Francesca Maria Coassin, Elisa Drigo, Annalisa Chiovati, Paola Dassie, Andrea Franchin, Giovanni Minatel, Emilio Trovò, Mauro Gaetano Cancers (Basel) Article Helical Tomotherapy (HT) is a highly conformal image-guided radiation technique, introduced into clinical routine in 2006 at the Centro di Riferimento Oncologico Aviano (Italy). With this new technology, intensity-modulated radiotherapy (IMRT) is delivered using a helicoidal method. Here we present our dosimetric experiences using HT in 100 children, adolescents and young adults treated from May 2006 to February 2011. The median age of the patients was 13 years (range 1–24). The most common treated site was the central nervous system (50; of these, 24 were craniospinal irradiations), followed by thorax (22), head and neck (10), abdomen and pelvis (11), and limbs (7). The use of HT was calculated in accordance to the target dose conformation, the target size and shape, the dose to critical organs adjacent to the target, simultaneous treatment of multiple targets, and re-irradiation. HT has demonstrated to improve target volume dose homogeneity and the sparing of critical structures, when compared to 3D Linac-based radiotherapy (RT). In standard cases this technique represented a comparable alternative to IMRT delivered with conventional linear accelerator. In certain cases (e.g., craniospinal and pleural treatments) only HT generated adequate treatment plans with good target volume coverage. However, the gain in target conformality should be balanced with the spread of low-doses to distant areas. This remains an open issue for the potential risk of secondary malignancies (SMNs) and longer follow-up is mandatory. Molecular Diversity Preservation International (MDPI) 2011-10-25 /pmc/articles/PMC3763405/ /pubmed/24213120 http://dx.doi.org/10.3390/cancers3043972 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mascarin, Maurizio
Giugliano, Francesca Maria
Coassin, Elisa
Drigo, Annalisa
Chiovati, Paola
Dassie, Andrea
Franchin, Giovanni
Minatel, Emilio
Trovò, Mauro Gaetano
Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues
title Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues
title_full Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues
title_fullStr Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues
title_full_unstemmed Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues
title_short Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues
title_sort helical tomotherapy in children and adolescents: dosimetric comparisons, opportunities and issues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763405/
https://www.ncbi.nlm.nih.gov/pubmed/24213120
http://dx.doi.org/10.3390/cancers3043972
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