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Mechanisms of RNA-induced toxicity in CAG repeat disorders

Several inherited neurodegenerative disorders are caused by CAG trinucleotide repeat expansions, which can be located either in the coding region or in the untranslated region (UTR) of the respective genes. Polyglutamine diseases (polyQ diseases) are caused by an expansion of a stretch of CAG repeat...

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Detalles Bibliográficos
Autores principales:	Nalavade, R, Griesche, N, Ryan, D P, Hildebrand, S, Krauß, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763438/ https://www.ncbi.nlm.nih.gov/pubmed/23907466 http://dx.doi.org/10.1038/cddis.2013.276

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