GADD34 induces cell death through inactivation of Akt following traumatic brain injury

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Neuronal cell death contributes significantly to the pathology of traumatic brain injury (TBI) irrespective of the mode or severity of the injury. Activation of a pro-survival protein, Akt, is known to be regulated by an E3 ligase TRAF6 through a process of ubiquitination-coupled phosphorylation at...

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Detalles Bibliográficos
Autores principales: Farook, J M, Shields, J, Tawfik, A, Markand, S, Sen, T, Smith, S B, Brann, D, Dhandapani, K M, Sen, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763442/
https://www.ncbi.nlm.nih.gov/pubmed/23907468
http://dx.doi.org/10.1038/cddis.2013.280

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