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GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Neuronal cell death contributes significantly to the pathology of traumatic brain injury (TBI) irrespective of the mode or severity of the injury. Activation of a pro-survival protein, Akt, is known to be regulated by an E3 ligase TRAF6 through a process of ubiquitination-coupled phosphorylation at...

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Detalles Bibliográficos
Autores principales: Farook, J M, Shields, J, Tawfik, A, Markand, S, Sen, T, Smith, S B, Brann, D, Dhandapani, K M, Sen, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763442/
https://www.ncbi.nlm.nih.gov/pubmed/23907468
http://dx.doi.org/10.1038/cddis.2013.280