Rad54 is required for the normal development of male and female germ cells and contributes to the maintainance of their genome integrity after genotoxic stress

Rad54 is an important factor in the homologous recombination pathway of DNA double-strand break repair. However, Rad54 knockout (KO) mice do not exhibit overt phenotypes at adulthood, even when exposed to radiation. In this study, we show that in Rad54 KO mouse the germline is actually altered. Comp...

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Detalles Bibliográficos
Autores principales: Messiaen, S, Le Bras, A, Duquenne, C, Barroca, V, Moison, D, Déchamps, N, Doussau, M, Bauchet, A-L, Guerquin, M-J, Livera, G, Essers, J, Kanaar, R, Habert, R, Bernardino-Sgherri, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763443/
https://www.ncbi.nlm.nih.gov/pubmed/23949223
http://dx.doi.org/10.1038/cddis.2013.281

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